geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical detection of tissue-infiltrating lymphocytes in mild urothelial dysplasia


, : Immunohistochemical detection of tissue-infiltrating lymphocytes in mild urothelial dysplasia. British Journal Of Urology. 72(6): 881-886

The presence and distribution of immunocompetent cells in normal and dysplastic urothelium of the bladder were investigated in 3 patients. Using an indirect immunoperoxidase staining procedure, monoclonal antibodies reacting with B (Leu 12+) and T (Leu4+) cells, cells of the suppressor/cytotoxic (Leu2a+), helper/inducer (Leu3a+) and natural killer (Leu7+) phenotypes, monocyte-macrophages (LeuM3+), and cells expressing interleukin-2 receptor and HLA-DR antigen (HLA-DR+) were tested in all specimens. The results confirmed the presence of a well ordered and compartmentalised distribution of immunocompetent cells in the normal mucosa far from dysplasia. There was an increased number of lymphocytes in the hyperplastic/dysplastic urothelium with associated Von Brunn's nests. Leu2a + cells, HLA-DR expressing cells and monocyte-macrophages were present inside the epithelium, particularly within dysplasia and von Brunn's nests, but the Leu3a+/Leu2a+ ratio was not inverted (0.48+0.1 to 0.74+0.2). These findings reveal that in mild urothelial dysplasia with von Brunn's nests there is a spatial modification of the immunological barrier associated with the mucosa.

US$19.90

PMID: 8306150

DOI: 10.1111/j.1464-410x.1993.tb16290.x


Other references

Homan, R.-Newcomb; Regosin, J., V.; Rodrigues, D., M.; Reed, J.M.chael; Windmiller, B., S.; Romero, L.M.chael, 2003: Impacts of varying habitat quality on the physiological stress of spotted salamanders (Ambystoma maculatum). We sampled blood from free-living spotted salamanders (Ambystoma maculatum) to test whether differences in the concentrations of a stress hormone (corticosterone) were associated with different qualities of breeding and migration habitat. Spotted...

Hirai Y.; Hagiwara A.; Yamazaki T., 1986: Efficient synthesis of racemic emetine and racemic protoemetinol by the stereoselective intramolecular michael reaction. The intramolecular Michael Reaction of 8 and 12 gave stereoselectively 9 and 13, which were converted to the emetine precursor (11) and (.+-.)-protoemetinol (2).

Duenges W.; Kiesel K., 1979: Microliter techniques for the gas chromatographic trace analysis of biological material. Naunyn-Schmiedeberg's Archives of Pharmacology 307(SUPPL): R13

Enzensberger, W.; Enzensberger, R.; Doerr, H.W.; Fischer, P.A., 1990: Risk of HIV infection in neurology. Der Nervenarzt 61(4): 250-251

Report O.Med Research Council, 1959: Vaccination against Whooping-Cough. The protective effect of 19 different vaccines against pertussis in children has been studied in a number of centers since 1942. The poorest gave an attack rate in home contacts of 87%, the most effective, an attack rate of 4%. Laboratory tests of...

Kinoshita, M.; Tanaka, H.; Arita, H.; Goto, Y.; Oshino, S.; Watanabe, Y.; Yoshimine, T.; Saitoh, Y., 2015: Pituitary-Targeted Dynamic Contrast-Enhanced Multisection CT for Detecting MR Imaging-Occult Functional Pituitary Microadenoma. Although resection of a tumor by trans-sphenoidal surgery is considered the criterion standard for successful surgical treatment of functional pituitary microadenoma, MR imaging occasionally fails to visualize and identify the tumor and supplement...

Kleiger, B., 1966: Anomalies of the posterior tibial tendon observed during medial release operation. Bulletin of the Hospital for Joint Diseases 27(1): 9-17

Libetta, C.; Meloni, F.; Centore, F.; Bulgheroni, A.; Napodano, P.; Dal Canton, A., 1999: Plasma levels and blood mononuclear cell release of IL-18 in patients on hemodialysis. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 290A, Sept

Rolland, R.M.; Kaufman, G.; Pokras, M.; Tabor, G., 1998: Conservation medicine: an emerging approach to protection of biodiversity. American Zoo and Aquarium Association Regional Conference Proceedings, 551-554

Strickertsson, J.A.B.; Desler, C.; Rasmussen, L.Juel., 2017: Bacterial infection increases risk of carcinogenesis by targeting mitochondria. As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondr...