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Immunohistochemical determination of pS2 in invasive breast carcinomas: A study on 942 cases

, : Immunohistochemical determination of pS2 in invasive breast carcinomas: A study on 942 cases. Breast Cancer Research and Treatment 34(2): 119-128

To assess the practical prognostic value of pS2, we evaluated its expression by immunohistochemistry in paraffin-embedded tissue from 942 previously untreated invasive ductal carcinomas (IDC) resected in our center between 1980 and 1986. Positive staining of tumor cells was found in 684 cases (73%), but most of the tumors contained only a small amount of positive cells. There was a negative correlation between pS2 and tumor size (p = 0.01) and histological grade (p lt 0.0001), and a positive correlation between pS2 and hormonal receptor status (p lt 0.001). With respect to overall survival, pS2 positivity was associated with a better prognosis for the whole group and the node-positive sub-group. However, in terms of relapse and metastasis, pS2 was not significant. Furthermore, in multivariate analysis including tumor size, nodal status, histological grade, ER status, PR status, chemotherapy, hormonal treatment, and pS2, the latter appears to be of no prognostic value.


PMID: 7647329

DOI: 10.1007/bf00665784

Other references

Smith David C., 2006: Dissolved organic carbon in interstitial waters, Equatorial Pacific and Peru Margin. This report contains dissolved organic carbon (DOC) concentration data from interstitial waters collected at three open-ocean sites (1225, 1226, and 1231) and four sites cored along the Peru margin (1227, 1228, 1229, and 1230) during Ocean Drillin...

Anonymous, 1965: Timber drying-air drying, technological drying, costing. A manual in 11 sections, each with its own bibliography, in which leading German authors discuss theory, practice and business economics of: air- and accelerated air-drying; conventional kiln drying (including veneers and chips); special methods s...

Pearson, K., 1934: On simometers and their handling. Neither Merejkowsky's nor Woo's simometer gives the true maximum distance of the arc of the nasal bridge from the chord. The cranial coordinatograph will do this. The length of the arc may be measured with a tape and the index calculated...

Hahm, K.B.ik; Oh, T.Y.ung; Nahm, K.T.ik; Kim, Y.B.e; Yoo, B.M.o; Lee, K.M.ung; Kim,; Cho, S.W.n; Joo, H.J.e, 2002: Nimesulide decreased Helicobacter pylori-associated gastric carcinogenesis in mice. Cancer Epidemiology Biomarkers & Prevention 11(10 Part 2): 1201s, October

Glass, H.E., 2004: Do clinical grant payment practices in phase 3 clinical trials influence subsequent clinical investigator prescribing behavior?. The advancement of science requires the cooperation of clinical investigators. Recent discourse, which attempts to relate pharmaceutical company grant payments to clinical investigators to subsequent preferential prescribing behavior, erodes the p...

Viikmaa, Mart., 1997: Evolutionary perspectives dependent on the size and subdivision of the populations Evolutsioonilised perspektiivid soltuvalt populatsioonide suurusest ja liigendatusest. Schola Biotheoretica, 23: 46-47

Lin, C.L.n; Liao,; Liu, C.J.n; Chen, P.J.r; Lai,; Kao, J.H.rng; Chen, D.S.inn, 2002: Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B. Background: Mutations in the precore stop codon (G1896A) and the basal core promoter (A1762T and G1764A) are frequently found in hepatitis B envelope antigen (HBeAg)-negative chronic hepatitis B. However, the clinical significance of these mutatio...

Ginderow Daria; Cesbron Fabien, 1979: Crystal structure of aubertite. Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry Vol

Clo C.; Tantini B.; Caldarera C.M., 1979: Effect of various oxygen tensions on the transport of alpha amino iso butyric acid in cultures of myo cardial cells. Amino acid transport, measured by .alpha.-aminoisobutyrate uptake, was studied in confluent [chick embryo] myocardial cell cultures exposed to different O2 tensions. The rate of cellular uptake and accumulation of the inert amino acid increase wit...

Wlotzka F.; Spettel B.; Wanke H., 1973: On the composition of metal from Apollo 16 fines and the meteoritic component. Geochimica et Cosmochimica Acta 2, Suppl