geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin


, : Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin. Journal Of Dermatological Science. 16(1): 17-22,.

Cutaneous fatty acid-binding protein (C-FABP) has been newly discovered from rat skin. The immunohistochemical study revealed that C-FABP is strongly expressed in rat epidermis. Recently, a highly homologous protein to rat C-FABP was found in psoriatic epidermis, which is termed psoriasis-associated fatty acid-binding protein (PA-FABP). In the present study, we investigated the expression of PA-FABP in normal and pathological human skin using immunohistochemical techniques. In normal skin, PA-FABP was expressed in basal and prickle cell layers, and more strongly in the granular cell layer. The expression pattern of PA-FABP was similar to that of C-FABP in rat skin. In psoriatic skin, PA-FABP was expressed in suprabasal layers and more strongly in more differentiated keratinocytes. In squamous cell carcinoma, PA-FABP showed very strong expression in squamous nests. These results indicate that PA-FABP is a human homologue of C-FABP. Moreover, it is suggested that C-FABP has important roles in the transport and metabolism of fatty acids in epidermis and that altered lipid metabolism may affect the proliferation and/or differentiation of keratinocytes.

US$19.90

DOI: 10.1016/s0923-1811(97)00615-4


Other references

Raue, F.; Dralle, H.; Machens, A.; Bruckner, T.; Frank-Raue, K., 2017: Long-Term Survivorship in Multiple Endocrine Neoplasia Type 2B diagnosed before and in the new Millennium. Recent long-term outcome and survival data are lacking for patients with multiple endocrine neoplasia type 2B (MEN2B). To analyze long-term MEN2B outcome and define prognostic factors. Retrospective comparative study of 75 patients with MEN2B from...

Passos Bueno, M.R.; Moreira, E.S.; Vasques, L.R.; Marie, S.K.; Iughetti, P.; Vainzof, M.; Bashir, R.; Bushby, K.; Bakker, E.; Zatz, M., 1994: Confirmation of a third locus, at 2p, for autosomal recessive limb-girdle muscular dystrophy indicates that at least 4 genes are responsible for this condition. American Journal of Human Genetics 55(3 SUPPL ): A199

Landis, J.; Shaw, L.M., 2014: Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis. Insulin receptor substrate 1 (IRS-1) and IRS-2 are cytoplasmic adaptor proteins that mediate the activation of signaling pathways in response to ligand stimulation of upstream cell surface receptors. Despite sharing a high level of homology and th...

Vincurova, M.; Maar, D.; Schwartz, E., 1984: Mycobacterial infection at the transverse process of the 2d lumbar vertebra caused by Mycobacterium fortuitum. The authors report on a tuberculous infection at an unusual location, caused by trauma in the region of the transverse process of the second lumbar vertebra. The pathogen was identified as mycobacterium fortuitum. This is a conditionally pathogeni...

White, P.S.ott; Cai, H.; Torney, D.C.; Nolan, J.P., 2001: SNP scoring technologies Why are there so many?. Human Mutation 17(4): 327

Tahseen, Q.; Ahmad, I.; Jairajpuri, M.S.amim, 1992: Description and developmental biology of Plectus zelli, new species (Nematoda: Araeolaimida). Plectus zelli n. sp. is described and illustrated. It is closely related to P. opisthocirculus Andrassy, 1952 and P. inquirendus Andrassy, 1958, and also to P. sambesii Micoletzky, 1916. It has L = 0.57-0.83 min, a = 18-26, b = 3.5-5.0, c = 8-13,...

Takeda, F.; Shimazaki, Y.; Watanabe, T.; Inui, K.; Uchida, T.; Uesho, K.; Koshika, M.; Katou, H.; Sakamoto, K., 2002: Mid-term outcome of aortic arch operation for true aneurysms; using an axillary artery perfusion. To prevent cerebral infarction during perioperative period, we have used an axillary artery for systemic perfusion and selective cerebral perfusion for aortic arch operation. Since 1996, 34 aortic arch operations were performed in our institution....

Benderdour, M.; Hess, K.; Dzondo-Gadet, M.; Nabet, P.; Belleville, F.; Dousset, B., 1998: Boron modulates extracellular matrix and TNF alpha synthesis in human fibroblasts. Boric acid was not mitogenic for human fibroblasts and it did not change cell viability until 0.5% (w/v). Boric acid treatment affected the metabolism of human dermal fibroblasts in culture, decreasing the synthesis of extracellular matrix macromo...

Struzhkin, V.V.; Hemley, R.J.; Mao, H.K.ang, 1997: Superconductivity at 10-17 K in compressed sulphur. A study explored the possibility of superconductivity in a material at very high pressures. At 93 GPa, elemental sulfur was seen to transform not only to a metal but to a superconductor with a transition temperature, Tc, of 10.1 K. Tc was found to...

Pellegrini, N.C.rsi, A.T.ccini, E.R.nzoni, G.T.sini, L., 1981: Pollution due to sedimentary solid particles with fine granular values in the Frigido and Versilia rivers. Chamical, physical and bacteriological findings in their waters. Annali della Facolta di medicina veterinaria di Pisaub 1981) 33(33): 229-238