+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evaluation of GFAP in salivary gland tumors

, : Immunohistochemical evaluation of GFAP in salivary gland tumors. Acta Histochemica et Cytochemica 29(2): 85-92

The present study deals with the immunohistochemical evaluation of glial fibrillary acidic protein (GFAP) in salivary gland tumors and the results are compared with vimentin, cytokeratin (K8.12) and S100 protein. In normal tissue from tumors of the salivary gland, the myoepithelium did not express GFAP. In glandular tissues adjacent to tumor or invaded by carcinoma, GFAP was detected in flattened and spindle shaped cells that surrounded intercalated ducts and atrophic acinar structures. In pleomorphic adenoma, the nonluminal cells in tubulo-ductal structures and modified or neoplastic myoepithelial cells which formed solid, myxoid and chondroid structures showed intense immunoreactivity for GFAP. GFAP was also detected in basally located tumor cells in adenoid cystic carcinoma and papillary-cystadenocarcinomas. Those cells corresponding to the GFAP positive cells were also positive for vimentin, cytokeratin (K8.12) and S100 protein. The results of the present study allow us to suggest that the salivary gland tumors may originate from basal cells of intercalated ducts and the basal cells may be closely related with neural ectoderm.


DOI: 10.1267/ahc.29.85

Other references

Lattouf, O.M.; Adams, K.N., 2014: Current readings on off-pump coronary artery bypass. Historically, the use of cardiopulmonary bypass (CPB) in performing coronary artery bypass grafting (CABG) has been the "gold standard" in coronary revascularization. However, with greater understanding of the inflammatory effects of CPB...

Lee, E.Kyung.; Gutcher, S.Thomas.; Douglass, A.Bruce., 2014: Is sleep-disordered breathing associated with miscarriages? An emerging hypothesis. Sleep-disordered breathing (SDB) is a common disorder that has numerous medical consequences including cardiovascular morbidity. The clinical presentation in women is frequently vague, leading to its under-recognition in this population. Sleep is...

Zaviacic M.; Brozman M.; Blazekova J.; Duris I., 1979: Effects of time restricted feeding and of changes in lighting conditions on the circadian rhythms of enzymes in the rat gastric mucosa. Chronobiologia 6(2): 175

Livshits, V.A., 1973: Mapping of mutations affecting the ability of Escherichia coli purine auxotrophs to use guanine and xanthine for growth. Genetika 9(11): 134-139

Kuttelwascher, Heide, 1965: Developmental anatomical study of air exposed orchid roots. The vital staining method to fixed and to living tissues were applied in order to study cellular changes occuring during the development of orchid roots. The presence of storage substances such as flavonoids and tanning agents in the vacuoles can...

Zheltikov, A., 2016: Spatiotemporal modulation instability as off-axis parametric amplification: insights from the phase. The canonical linear-stability analysis of spatiotemporal modulation instability (MI), which treats MIs as instabilities of the steady-state solution of the field evolution equation with respect to weak complex harmonic perturbations, is shown to...

Jourenkova-Mironova, N.; Voho, A.; Bouchardy, C.; Wikman, H.; Dayer, P.; Benhamou, S.; Hirvonen, A., 1999: Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Glutathione S-transferases (GSTs) are involved in detoxification of reactive metabolites of carcinogens and, therefore, could be potentially important in susceptibility to cancer. The associations between larynx cancer risk and GSTM3 and GSTP1 gen...

Heilmann, J.; Barollier, J.; Watzke, E., 1957: Amino acid estimation on paper chromatograms. A reagent containing cadmium acetate, acetic acid, ninhydrin and acetone is used. After colour development the spots are eluted with methanol and the amino acids are estimated spectrophotometrically.

Richmond, C.R.; Furchner, J.E.; Trafton, G.A., 1962: Use of whole body counting to investigate effects of whole body x-irradiation on metabolic parameters. I. Uptake and retention of strontium 85 by rats. La Reports . U.S. Atomic Energy Commission Lams-2780: 50-56

Cys John M., 1969: On the term cryptalgalaminate, a discussion. The abandonment of the term 'cryptalgalaminate' in favor of the term 'algal mat' is advocated.