geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms


, : Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Human Pathology. 27(2): 119-124

Although several morphological and molecular genetic studies have implicated various grades of pancreatic duct hyperplasia as precursor lesions to infiltrating pancreatic adenocarcinoma, the identity of preinvasive pancreatic neoplasms remains controversial. In the present study, the authors examined the expression of the epidermal growth factor receptor homologue, HER-2/neu (c-erbB-2), in pancreatic duct lesions adjacent to infiltrating pancreas cancers in a series of 19 cases of pancreatic duct adenocarcinoma. HER-2/neu expression was examined because it has been identified in a proportion of infiltrating pancreas cancers and because it may provide early neoplasms with a growth advantage over adjacent nonneoplastic epithelium. In normal pancreatic ducts and ductules, HER-2/neu expression was absent in all but one case. By contrast, HER-2/neu was expressed in 82% (P = .008 vs normal ) of ducts with flat mucinous hyperplasia, 86% (P = .03 vs normal) of ducts with papillary mucinous hyperplasia without atypia, 92% (P = .001 vs normal) of ducts with atypical papillary mucinous hyperplasia, and all specimens with carcinoma in situ. HER-2/neu expression was observed in 69% (P = .002 vs normal) of the moderately differentiated infiltrating carcinomas and none of the poorly differentiated infiltrating carcinomas. These data establish HER-2/neu as a potential mediator of growth factor-related signal transduction in pancreatic duct lesions, and provide additional support for the hypothesis that lesions formerly regarded as various grades of hyperplasia instead may represent intraepithelial neoplasms with the potential for subsequent invasion and metastasis.

US$19.90

PMID: 8617452

DOI: 10.1016/s0046-8177(96)90364-0


Other references

Woody, C.D.; Brozek, G., 1969: Changes in evoked responses from facial nucleus of cat with conditioning and extinction of an eye blink. Journal of Neurophysiology 32(5): 717-725

Herbitter, C.; Bennett, A.; Schubert, F.D.; Bennett, I.M.; Gold, M., 2014: Management of early pregnancy failure and induced abortion by family medicine educators. Reproductive health care, including treatment of early pregnancy failure (EPF) and induced abortion, is an integral part of patient-centered care provided by family physicians, but data suggest that comprehensive training is not widely available t...

Pieler, T.; Digweed, M.; Erdmann, V.A., 1985: RNA structural dynamics: pre-melting and melting transitions in E. coli 5S rRNA. The temperature dependent transition from duplex to a single strand in E. coli 5S ribosomal RNA is a multistep process, and it involves intermediate states. We have analyzed these structural dynamics by chemical modification of cytidines and by si...

Naghavi, S.Ebrahim.; Jalali, M.Mohammad., 2003: Papillary carcinoma of thyroglossal duct cyst. Thyroglossal duct cysts are the most common congenital abnormality of thyroid development. They represent the most common midline neck masses in childhood, however, can be found in adults. Less than 1% of these cases are malignant. Our patient was...

Warden, N.A.; Hood, K.; O'brien, P.; Styne, D., 2000: Maternal and child factors associated with successful weight management by 6-10 year old obese children during a 12 week weight management intervention. Pediatric Research 47(4 Part 2): 233A, April

Berbecar, S., 1997: Legionellosis: clinical and epidemiological data. Legionellosis is a contagious disease occurring either sporadically or more frequently in outbreaks, the infections being caused by members of the family Legionellaceae. The disease may show two clinical forms, i.e.: 1) the pneumonic form characte...

Pergolizzi, J.V.; Curro, F.A.; Col, N.; Ghods, M.Papa.; Vena, D.; Taylor, R.; Naftolin, F.; LeQuang, J.Ann., 2017: A multicentre evaluation of an opioid patient-provider agreement. The role of the patient-provider agreement (PPA) is to set forth respective roles and responsibilities for opioid therapy with the goal of improving outcomes, reducing risks, and improving patient education. The Food and Drug Administration (FDA)...

Jofre Giraudo, E.; Streeter, D.H.; Lazarus, W.F., 1990: The impact of computer information systems on dairy farm management decisions. This study focuses on whether information systems improve farm management. Fifty New York dairy farms were selected, based on their use of computerized information systems. Each computer user was matched with a non-computer-using farm. On- farm in...

Fuss, E., 1978: Nursing in hepatitis. Osterreichische Krankenpflegezeitschrift 31(1): 26-31

Sawchuk, M.A.; Hossain, M.Z.; Hertzberg, E.L.; Nagy, J.I., 1995: In situ transblot and immunocytochemical comparisons of astrocytic connexin-43 responses to NMDA and kainic acid in rat brain. Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction p...