geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evaluation of cellular deposits on posterior chamber intraocular lenses


, : Immunohistochemical evaluation of cellular deposits on posterior chamber intraocular lenses. Graefe'S Archive For Clinical & Experimental Ophthalmology. 236(10): 758-765,.

Purpose: We used immunohistochemistry to characterize cellular and proteinaceous deposits on the surfaces of explanted posterior chamber intraocular lenses (PCIOLs). Methods: A total of 30 PC-IOLs were immunostained for the alpha- or beta-subunits of prolyl 4-hydroxylase, which is involved in collagen biosynthesis; cellular fibronectin; aB crystalline; and CD68, a macrophage marker, to characterize the cellular deposits that adhere to the IOL surfaces and to evaluate the distribution of cells involved in the deposition of extracellular matrix on IOLs. Results: Cellular or proteinaceous deposits were observed on all 30 PCIOLs. Cells that showed positive staining for aB crystallin were classified as lens epithelial cells; CD68-positive cells were considered to be of macrophagic origin. Positivity for cellular fibronectin, including the macrophages and related cells, appeared to be responsible for the accumulation of fibronectin on the surfaces of PC-IOLs. Prolyl 4-hydroxylase-positive cells were involved in the deposition of collagen on PCIOLS. Conclusion: Immunohistochemical study revealed that macrophages, foreign-body giant cells, and lens epithelial cells adhered to explanted PC-IOLs. Such adherent cells are responsible for the deposition of extracellular matrix on the surfaces of PC-IOLs and may regulate the assembly of the extracellular matrix, influencing the biocompatibility of PC-IOLs.

US$19.90

PMID: 9801891

DOI: 10.1007/s004170050155


Other references

Akcasu A., 1973: The possible role of mast cells in the withdrawal syndrome precipitated by the injection of nalline to the addicted dog. Pahlavi Medical Journal 4(4): 503-517

Seki, M.; Ohta, H.; Yanagisawa, A.; Et-Al, 2003: Gastric-type duodenal adenoma in the shape of submucosal tumor (SMT) accompanied by a gastric cancer, report of a case. A 64-year-old man was diagnosed by a physician of a neighboring hospital endoscopically, as having both a gastric cancer and a duodenal SMT-like tumor simultaneously. He was admitted to our hospital for more precise examination. The duodenal tumor...

Giard, A., 1900: Developpement des oeufs d'Echinodermes sous l'influence d'actions kinetiques anormales (solutions salines et hybridation). Compte Rendu des Seances de la Societe de Biologie, lii 442-444

D.S.; S.D.; S.B., 2016: Rare presentation of a common disease. Journal of the Association of Physicians of India 64(1): 56-56

Wang, G.; Wang, H.; Wang, Z.; Xue, K.; Ma, C.; Feng, A.; Tian, Y., 2015: Study of IFN-α in combination with all-trans retinoic acid on the proliferation and differentiation of acute promyelocytic leukemia cell lines NB4 and NB4-R1 cells. Zhonghua Xue Ye Xue Za Zhi 36(2): 166-167

Stiffler D.F.; Ryan S.L.; Mushkot R.A., 1985: Interactions between acid base balance and epidermal electrolyte transport in amphibia. Federation Proceedings 44(4): 1347

Morgagni, G.L.igi; Pomarici, E.; Simoni, C.; Fiorentini, G.; Coralli, M.; Rusticali, F., 1993: Detection of hibernating myocardium during cardiac catheterization by enoximone administration. Journal of the American College of Cardiology 21(2 SUPPL A): 109A

Kulkarni, S.K.; Jain, N.K., 1999: Feverfew Ancient remedy for multiple disorders. Drugs of the Future 24(12): 1339-1343, Dec

Remafedi, G.; Lauer, T., 1996: The health and psychosocial status of HIV-seropositive youth in Minnesota. To describe the health outcomes and health care utilization of nonhemophiliac adolescents diagnosed with human immunodeficiency virus (HIV) infection. Cross-sectional survey. All state residents without hemophilia, 13-21 years of age at the time o...

Cox-York, K.A.; Erickson, C.B.; Pereira, R.I.; Bessesen, D.H.; Van Pelt, R.E., 2016: Region-specific effects of oestradiol on adipose-derived stem cell differentiation in post-menopausal women. NlmCategory="UNASSIGNED">The goal of this study was to determine the effect of acute transdermal 17β-oestradiol (E<sub>2</sub> ) on the adipogenic potential of subcutaneous adipose-derived stem cells (ASC) in post-menopau...