+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evaluation of multiple biological markers in ductal carcinoma in situ of the breast

, : Immunohistochemical evaluation of multiple biological markers in ductal carcinoma in situ of the breast. European Journal Of Cancer. 32a(7): 1148-1155

In order to obtain prognostic clinicopathological information, 49 cases of pure ductal carcinoma in situ of the breast (DCIS), were evaluated for the immunohistochemical expression of potential predictor markers including c-erbB-2 oncogene product, p53 protein, oestrogen (ER) and progesterone (PR) receptors, oestrogen-regulated proteins pS2 and cathepsin-D (cath-D), CD44 protein and 67-kDa laminin receptor (MLuC5). Immunohistochemical findings were compared with conventional pathological parameters, clinical findings, and the clinical outcome of the patients. When markers were matched to each other, statistical analyses provided a significant positive correlation between c-erbB-2 overexpression and p53 positivity (P lt 0.01) and between ER and PR (P lt 0.01), ER, PR and pS2 (P lt 0.01), pS2 and MLuC5 (P lt 0.05). Significant negative correlations between c-erbB-2 overexpression and ER (P lt 0.05), PR (P lt 0.01) and pS2 (P lt 0.01) positivity was also observed. Data on the relationship between marker status and pathological findings revealed a significant positive trend between c-erbB-2, p53, and increased grade values (P lt 0.05) and opposite results with PR receptor expression (P lt 0.01). c-erbB-2 overexpression was further significantly associated with comedotype carcinoma (P lt 0.05) and distribution of disease in confluent neoplastic ducts (P lt 0.01). Although no statistically significant correlation among biological markers expression, clinical findings and outcome was demonstrated, overall this study indicates that tumour cells from a subset of DCIS, which includes comedotype carcinoma, express significantly unfavourable prognostic factors.


PMID: 8758245

DOI: 10.1016/0959-8049(96)00037-8

Other references

Atwood, H.L.; Young, S.P.; Tomasso, J.R.J.; Smith, T.I.J., 2004: Information on selected water quality characteristics for the production of black sea bass, Centropristis striata juveniles. Recent interest in the culture of black sea bass, Centropristis striata, has led to questions regarding the environmental requirements of this species for economically-viable production. Here we present the results of short-term laboratory studies...

Warner R.R.P.; Mitty H.A.; Hafner D.G., 1973: Nonspecific takayashu arteritis and ischemic disease of the intestine. Gastroenterology 64(4): A-134-817

Béry, A., 1990: Conditions required for formation of a contract of care. Revue D'orthopedie Dento-Faciale 24(1): 111-117

Anonymous, 1986: Homicide: the public health perspective. Bulletin of the New York Academy of Medicine 62(5): 373-624

Shotzberger, G.S.; Albuquerque, E.X.; Daly, J.W., 1976: The effects of batrachotoxin on cat papillary muscle. The effects of batrachotoxin (BTX) upon the contraction and transmembrane potential of cat right ventricular papillary muscles were studied in vitro at 37 degrees C. BTX (2.0 x 10(-9) M) increased isometric contractile force by about 50% from cont...

Coman, B.J., 1973: The diet of red foxes, Vulpes vulpes L., in Victoria. The stomach contents of 1229 foxes collected in Victoria during 1968-70 were studied. Of the stomachs 967 contained measurable amounts of food. The main foods seemed to be rabbits, sheep, of which little was identified as having been fresh when ea...

Yamagishi, H.; Olson, E.N.; Srivastava, D., 2000: The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. Reciprocal interactions between vascular endothelial cells and vascular mesenchymal cells are essential for angiogenesis. Here we show that the basic helix-loop-helix transcription factor, dHAND/Hand2, is expressed in the developing vascular mesen...

Hull, E., 1895: On the physical conditions of the Mediterranean Basin which Lave resulted in a community of some species of freshwater Fishes in the Nile and the Jordan waters. Abstract. E. HULL, Quart. J. Geol. Soc. li, p. 93, remarks on the physical con-ditions of the Mediterranean basin, which have resulted in a community of some species of freshwater Fishes in the Nile and the Jordan.

Stohlman, F.; Brecher, G., 1956: Stimulation of erythropoiesis in sublethally irradiated rats by a plasma factor. Single intravenous injections of plasma from anemic donor rats increased erythropoiesis in sublethally irradiated rats when compared with plasma from normal rats. Differences in erythropoiesis were measured by Fe59 incorporation into red cells and...

Chen, Z.Y.; Shie, J.L.n; Tseng, C.C.uan, 2002: STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression. Gut-enriched Kruppel-like factor (GKLF/KLF4), a member of the Kruppel-like factor family of transcription factors, has recently been shown to be associated with growth arrest in the colonic mucosa. Our laboratory has previously demonstrated that G...