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Immunohistochemical evaluation of p53 and retinoblastoma proteins in relation to hyperthermia treatment: results in human urothelial carcinomas

, : Immunohistochemical evaluation of p53 and retinoblastoma proteins in relation to hyperthermia treatment: results in human urothelial carcinomas. International Journal of Hyperthermia 12(6): 813-824

Immunohistochemical staining of urothelial tumours using paraffin-embedded tissue blocks was performed for p53 and Retinoblastoma (RB) proteins, to characterize any correlation with sensitivity to hyperthermia treatment. Seventeen patients with primary urothelial tumours (16 of the bladder and one of the ureter) treated at our institute between July, 1987 and March, 1993 were included in this study; tissues investigated consisted of 16 transitional cell carcinomas (TCC) (6 Grade2 (G2), 6 G3, 2 G2 > G3, 1 G3 > squamous cell carcinoma (SCC), 1 undifferentiated carcinoma > G3), and 1 SCC. One case was Tis, 4, 3, 1, and 4, were T1 to T4, respectively, and 4 were post-cystectomy. Clinically, in terms of response to treatment, there were four complete response (CR) cases, four partial response (PR) cases, six no change (NC) cases, and three progressive disease (PD) cases, the total in which treatment was effective thus accounting for approximately half of those examined (CR + PR, 47%). Immunohistochemically, six of eight pre-hyperthermia lesions which demonstrated positive staining for RB were CRs or PRs, 75% of which were high-grade lesions, and 50% exhibited invasion and lymph node metastasis. Only three in total were positive for p53 staining, two of which were T4 and these both responded to treatment. The results suggested that RB gene expression may be related to heat sensitivity to some degree.


PMID: 8950161

DOI: 10.3109/02656739609027687

Other references

Misawa, T.; Yamamoto, S.; Tani, S., 1980: Varietal differences in resistance to Pseudomonas avenae in Eleusine. Significant differences in lesion size were observed in inoculation tests of 14 varieties in 1978 and 24 varieties in 1979. The varieties were placed in three groups according to lesion length: under 10 mm, 11-19 mm and over 20 mm. Puruna and 73-3...

Pershin, G.N.; Zykova, T.N., 1958: The catalase activity of tuberculous mycobacteria. Probl Tuberkuleza 7: 83-90

Pierro, A., 1997: Necrotizing enterocolitis: pathogenesis and treatment. British Journal of Hospital Medicine 58(4): 126-128

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