geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evidence for a neurotensin striatonigral pathway in the rat brain


, : Immunohistochemical evidence for a neurotensin striatonigral pathway in the rat brain. Neuroscience. 55(3): 833-847

The distribution and origin of neurotensin-like immunoreactivity in the substantia nigra pars reticulata of the rat have been analysed using immunohistochemistry combined with different drug treatments and lesioning techniques. In normal rats, a distinct but weakly fluorescent network of neurotensin-immunoreactive fibers was found in the central part of the substantia nigra pars reticulata. When the animals were treated with reserpine, which suppresses dopamine transmission, a similar pattern of immunoreactivity was found, though the intensity of staining was slightly enhanced. However, when rats were treated with methamphetamine, a potent dopamine releaser, the intensity of immunoreactivity was dramatically increased. In particular, densely packed neurotensin-immunoreactive fibers were found at the dorsal border and at the ventral periphery of the substantia nigra pars reticulata. This pattern of immunoreactivity was found to be similar to that displayed by dynorphin. In the nucleus caudatus, several neurotensin-immunoreactive cell bodies were seen after reserpine treatment. Morphologically similar perikarya were observed in methamphetamine-treated rats, but they were less numerous, whereas no cell bodies were detectable in untreated animals. When a unilateral mechanical transection or an ibotenic acid injection was performed in the striatum, the patterns of neurotensin as well as dynorphin and substance P immunoreactivities in the substantia nigra pars reticulata were strongly affected. Both types of lesion caused a marked, parallel depletion of all three immunoreactive substances on the side ipsilateral to the lesion, where a restricted area was virtually devoid of immunoreactive elements. Thus the present study provides evidence for the existence of a unilateral neurotensin striatonigral pathway, terminating in the pars reticulata. The origin of the neurotensin fibers in the pars compacta has not been established but does not appear to be the caudate nucleus. These results together with evidence from the literature suggest that methamphetamine induced a massive release of dopamine from nigral dendrites acting on presynaptic D-1 dopamine receptors located on neurotensinergic terminals leading to a marked increase in neurotensin-like immunoreactivity in the pars reticulata.

US$19.90

PMID: 8105419

DOI: 10.1016/0306-4522(93)90445-L


Other references

Mak, A.; Kow, N.Yee., 2014: The pathology of T cells in systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies. Thus, the condition was traditionally classified as a "B-cell disease". Compelling evidence has however shown that without the assis...

Radeloff, V.C.; Hammer, R.B.; Voss, P.R.; Hagen, A.E.; Field, D.R.; Mladenoff, D.J., 2001: Human demographic trends and landscape level forest management in the northwest Wisconsin Pine Barrens. The effects of landscape pattern on forest ecosystems have been a recent focus in forest science. Forest managers are increasingly considering landscape level processes in their management. Natural disturbance patterns provide one baseline for suc...

Lancaster, J.Steven, 1992: Chemiluminescence detection in analytical chemistry. Chemiluminescence as a consequence of biological processes and — more recently — in organic chemical reactions has long been known, though the mechanisms involved are still not fully understood. In recent years chemiluminescence has become the...

Carcione, Jé.M.; Helbig, K., 2008: Elastic medium equivalent to Fresnel's double-refraction crystal. In 1821, Fresnel obtained the wave surface of an optically biaxial crystal, assuming that light waves are vibrations of the ether in which longitudinal vibrations (P waves) do not propagate. An anisotropic elastic medium mathematically analogous t...

Nozaki H.; Goto N.; Nara T., 1992: Development of the human pontine nuclei a morphometric study. The morphometric development of the pontine nuclei in the human fetus from 16 to 40 gestational weeks, in 2-month-old infant and in a 63-year-old adult were examined employing a serial celloidin section method and computer assisted electronic plan...

MunirAhmad; Chaudhry,M.H.; Amjed,M.T., 2008: Effect of irrigation frequencies on grain yield of maize. To find out the water requirement and its application frequencies in spring Maize a trial was designed The trial was comprised of five maize varieties (Ev-5098, EV-6098, EV-1098, Composite-20 and Pak Afgoyee) and five irrigation frequencies (7, 8,...

Pan, Y.; Garg, A.; Agarwal, A.K., 2007: Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells. Mature lamin A is formed after post-translational processing of prelamin A, which includes prenylation and carboxymethylation of cysteine 661 in the CaaX motif, followed by two proteolytic cleavages by zinc metalloprotease (ZMPSTE24). We expresse...

Davids, K.; Glazier, P., 2010: Deconstructing neurobiological coordination: the role of the biomechanics-motor control nexus. Inherent indeterminacy of neurobiological systems has been revealed by research on coordination of multiarticular actions. We consider three important issues that these investigations raise for biomechanical measurement and performance modeling. T...

Milia, M.; Pinna, M.E.; Satta, M.; Scarpa, G.M., 1996: Glycyrrhiza glabra L.: micropropagation as an alternative to traditional propagation. The first 2-3 nodes of 2 accessions of liquorice were cultured in vitro on MS media containing a range of plant growth regulators. New shoot differentiation was greatest with 0.5 or 1 mg BA/litre and 0.25 mg NAA/litre. Results for the 2 accessions...

Schmid, A.; Zipf, K., 1965: Storage and distribution of strontium in chicken eggs. Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 12(7): 613-616