+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical evidence for the expression of proliferating cell nuclear antigen (PCNA) by non-proliferating hepatocytes adjacent to metastatic tumours and in inflammatory conditions

, : Immunohistochemical evidence for the expression of proliferating cell nuclear antigen (PCNA) by non-proliferating hepatocytes adjacent to metastatic tumours and in inflammatory conditions. Journal of Pathology 171(2): 115-122

The possibility that proliferating cell nuclear antigen (PCNA) is expressed by non-proliferating liver cells was investigated. Liver biopsies from 107 patients were investigated, which included histologically normal liver, metastatic tumour, and inflammatory lesions. PCNA was detected using immunohistochemical staining with the monoclonal antibody PC10. This was compared with the proportion of proliferating cells as assessed by immunostaining for the Ki-67 antigen using the monoclonal antibody MIB 1. Most cases of histologically normal liver showed few PC10-positive cells. PCNA-positive hepatocytes far outnumbered those positive with MIB 1 in specimens showing metastatic tumour or an inflammatory cell infiltrate. There was no relation between the degree of PCNA overexpression and the type of tumour present or the nature of the inflammatory lesion. Other cell types, including the biliary epithelium, did not show this large difference between the proportions of PC10- and MIB 1-positive cells. It is concluded that non-proliferating hepatocytes increase their levels of PCNA in a wide variety of pathological conditions. This may be mediated by cytokines released by tumour cells or inflammatory cells.


PMID: 7904308

DOI: 10.1002/path.1711710208

Other references

Volk, G.M., 1944: The significance of the soil nitrate test for cabbage. Below 3.5 ppm, the NO3-nitrogen level in the soil became a dominant limiting factor to the growth of cabbage with a developed root system. The limits for max. yield were between 8 and 25 ppm. The diphenylamine tissue test changed from weak to stro...

Rosenbluh, J.; Nijhawan, D.; Cox, A.G.; Li, X.; Neal, J.T.; Schafer, E.J.; Zack, T.I.; Wang, X.; Tsherniak, A.; Schinzel, A.C.; Shao, D.D.; Schumacher, S.E.; Weir, B.A.; Vazquez, F.; Cowley, G.S.; Root, D.E.; Mesirov, J.P.; Beroukhim, R.; Kuo, C.J.; Goessling, W.; Hahn, W.C., 2013: β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers; emerging evidence indicates that oncogenic β-catenin regulates several biological processes essential for cancer initiation and progression. To decipher the...

Wilson, C.M.; Wong, K.; Ng, J.; Cocker, K.D.; Ells, A.L.; Fielder, A.R., 2012: Digital image analysis in retinopathy of prematurity: a comparison of vessel selection methods. To evaluate vessel selection methods to distinguish between eyes with and without retinopathy of prematurity (ROP) and between different stages of ROP when quantifying the associated vessel changes in width and tortuosity semiautomatically from di...

Labhardt A.M.; Hunziker Kwik E.H.; Wuthrich K., 1988: Sequence specific proton nmr assignments and determination of the secondary structure of alpha neurotoxin from dendroaspis polylepis polylepis in aqueous solution. Experientia (Basel) 44(ABSTR): A35

Barrachina, L.; Remacha, A.Rosa.; Soler, L.; García, N.; Romero, A.; Vázquez, F.José.; Vitoria, A.; Álava, Mía.Ángeles.; Lamprave, Fín.; Rodellar, C., 2016: Acute phase protein haptoglobin as inflammatory marker in serum and synovial fluid in an equine model of arthritis. NlmCategory="UNASSIGNED">Acute phase proteins are useful inflammatory markers in horses. Haptoglobin (Hp) serum level is increased in horses undergoing different inflammatory processes, including arthritis. However, Hp concentration h...

Cahill, J., 1996: Psychosocial aspects of interventions in occupational safety and health. Attention to psychosocial hazards in work environments should become an increasingly important component of occupational safety and health interventions. Research findings have linked a number of measurable psychosocial characteristics with negati...

Palmquist, D.L.; Mattos, W., 1978: Turnover of lipoproteins and transfer to milk fat of dietary (1-Carbon-14) linoleic acid in lactating cows. Chylomicra and very low density lipoproteins labelled with [1-14C]linoleic acid were isolated from thoracic duct lymph of a calf fed the labelled fatty acid and were injected into lactating cows fed a control diet of hay, grain and maize silage (e...

Subramaniam, M.K., 1935: Preliminary observations on the effect of fertilization on the Golgi bodies in the eggs of Acentrogobius neilli. The Golgi elements lying below the zona radiata enlarge on fertilization. The rims of the fatty yolk droplets break up into irregular granules the majority of which also form a concentration below the zona radiata. Concurrently the inner portions...

Upadhyaya, S.; Cooke, J.; Pellerin, R.; Throop, J., 1981: Limb impact harvesting. II. Experimental approach. Transactions of the ASAE American Society of Agricultural Engineers 24(4): 864-867

Rhode P.R.; Elsasser S.; Campbell J.L., 1990: Mutational analysis of abf1. Yeast 6(SPEC ISSUE): S182