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Immunohistochemical evidence of neuronal and glial differentiation in retinoblastoma

, : Immunohistochemical evidence of neuronal and glial differentiation in retinoblastoma. British Journal of Ophthalmology 79(8): 771-776

Background: The study sought to investigate the histogenesis of retinoblastoma. Methods: One hundred specimens of retinoblastomas were examined along with those of 18 astrocytic gliomas and 15 medulloblastomas to compare similarities of glial differentiation in retinoblastoma and the two types of brain tumour. Employing avidin-biotin immunoperoxidase technique, antibodies were applied against neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein (S-100). Results: Most rosettes and fleurettes, and some undifferentiated cells in retinoblastomas were NSE positive, but GFAP and S-100 negative. GFAP and S-100 positive cells in retinoblastomas were detected mostly in well differentiated glial cells which were interpreted as reactive or nonneoplastic cells. Some of the GFAP and S-100 positive cells in retinoblastomas were defined as tumour cells that resembled neoplastic astrocytes in astrocytic gliomas and medulloblastomas. Conclusion-Retinoblastoma may arise from primitive bipotential or multipotential cells capable of neuronal and glial differentiation.


PMID: 7547791

DOI: 10.1136/bjo.79.8.771

Other references

Schoedel, W.; Slama, H.; Hansen, E., 1969: Time-dependent changes in the surface pressure of alveolar surface layers in the Langmuir trough. Pflugers Archiv 306(1): 20-32

de Zegher, F.; Francois, I.; van Helvoirt, M.; Van den Berghe, G., 1997: Clinical review 89: Small as fetus and short as child: from endogenous to exogenous growth hormone. Journal of Clinical Endocrinology and Metabolism 82(7): 2021-2026

Nordqvist A., 1984: ROCKDISC; a microcomputer-based core logging system. International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts 21(2): 109-112

Chan Lap yan; Goodman Richard E., 1987: Predicting the number of dimensions of key blocks of an excavation using block theory and joint statistics. Proceedings - Symposium on Rock Mechanics 28: 81-87

Wheeler, G., 1903: The butterflies of Switzerland and the Alps of Central Europe. Unknown

Waaben, J.; Sørensen, H.R.; Andersen, U.L.; Gefke, K.; Lund, J.; Aggestrup, S.; Laursen, H.; Gjedde, A., 1994: Brain damage following low flow cardiopulmonary bypass in pigs. Reduction of pump flow during cardiopulmonary bypass (CPB) reduces the formation of microemboli and trauma to the blood components, reduces both rewarming of the heart and the noncoronary collateral flow, and improves surgical exposure. Recent stu...

Anonymous, 2007: The ins and outs of outpatient procedures. Johns Hopkins Medical Letter Health After 50 18(12): 6-7

Lopez F.; Morales F.R.; Soja P.J.; Chase M.H., 1989: Pgo related hyperpolarizing potentials in lumbar motoneurons are mediated by an inhibitory amino acid. Society for Neuroscience Abstracts 15(1): 921

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