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Immunohistochemical examination of ubiquitin activating enzyme (E1) activity in neuronal degeneration


, : Immunohistochemical examination of ubiquitin activating enzyme (E1) activity in neuronal degeneration. Cerrahpasa Tip Dergisi 27(3): 139-141

Background: Recent studies show the joining of ubiquitin with abnormal and short life proteins with the help of ubiquitin activating enzyme. Design: Ubiquitin activating enzyme was purified from erythrocytes and injected to rabbits for antibody induction. Antibody specificity and reactivity were assessed by ELISA. Human brain tissue sections with neurodegeneration were used for immunohistochemical staining. Stained tissues were examined under light microscope.

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