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Immunohistochemical expression of carbohydrate antigen 19-9 in colorectal carcinoma

, : Immunohistochemical expression of carbohydrate antigen 19-9 in colorectal carcinoma. American Journal of Gastroenterology 89(1): 101-105

Objectives: Carbohydrate antigen 19-9 (CA19-9) is one of the most representative tumor markers in colorectal carcinomas. We studied the immunohistochemical expression of CA19-9 in primary colorectal carcinoma to identify its significance as a prognostic factor. Methods: The avidin-biotin-peroxidase complex method was used for CA19-9 staining in sections from 149 patients with primary colorectal carcinoma. The data were studied by univariate and multivariate analyses. Results: 86 tumors (56%) stained positively. The staining pattern was classified into three groups: group I (a stromal type, 22 tumors), group II (an apical and/or cytoplasmic type, 64 tumors), and group III (no staining, 63 tumors). Eight clinicopathologic variables showed a significant relationship with the staining pattern of CA19-9. The 5-yr survival rate of the group I subjects was significantly lower than that of the other two groups. With the multivariate analysis, the staining pattern of CA19-9 proved to be one of the independent prognostic variables. Conclusions: In addition to conventional prognostic factors, the staining pattern of CA19-9 is considered to be of value in predicting the prognosis of patients with colorectal carcinomas.


PMID: 8273774

Other references

Samani, N.J.; Vincent, M.; Sassard, J.; Henderson, I.W.; Kaiser, M.A.; Brammar, W.J.; Swales, J.D., 1990: Analysis of the renin gene intron A tandem repeat region of Milan and Lyon hypertensive rat strains. The region of intron A of the rat renin gene containing a unique tandemly repeated sequence was analysed in the Milan and Lyon hypertensive rat strains and their controls, and in several Sprague-Dawley rats, using an oligonucleotide probe compleme...

Baddley, J.W.; Perfect, J.; Warren, R.M.; Pankey, G.A.; Larsen, R.A.; Henderson, H.; Pappas, P.G., 2000: Pulmonary cryptococcosis in patients without HIV infection When is a lumbar puncture needed?. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 40: 365

Karelin A.A., 1986: Role of atp magnesium generated by plasma membranes in the mediation of signal transmission from insulin receptor and other regulators to membrane kinase. Vestnik Akademii Meditsinskikh Nauk SSSR (8): 77-90

Boogaerts M.A.; Malbrain S.; Roelant C.; Verwilghen R.L., 1985: Comparative influence of clindamycin and metronidazole on granulocyte function in vitro. Clinical Research 33(2 PART 1): 395A

Ramadas, S.R.; Kumaresan, S., 1989: Studies on thiasteroids part ii. investigations concerning the total syntheses of 12 thiasteroids 2 6 bisthiabenz 3 4 estra 3 5 10 8 14 tetraen 17 one and its d homo analogue and 2 6 16 tristhiabenz 3 4 d homoestra 3 5 10 8 14 tetraen 17a one. Syntheses of 12-thia-C-secosteroids starting from N-(1-naphthylmethylthio)succinimide (I) as well as the synthesis of racemic 2,6-bisthiabenz[3,4]estra-3,5(10)-8,14-tetraen-17 one (XI), its D-homo analogue(XIII) and 2,6,16-tristhiabenz[3,4]-D-homo...

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Anonymous, 2005: Statins for high-risk patients without heart disease or high cholesterol. Medical Letter on Drugs and Therapeutics 48(1225): 1-3

Thompson W.S.; Gross R.H., 1988: Antibodies introduced into living cells with liposomes localize specifically and inhibit specific intracellular processes. We have developed a system for efficiently packaging antibodies and other macromolecules into liposomes and then delivering the encapsulated molecules into living cells through liposome-cell fusion. Fusion is very efficient, and all cells can be d...

Beaver E.E.; Williams J.E.; Hannah S.M.; O'connor D.L.; Miller S.J., 1987: Performance diet digestibility body composition plasma hormone parameters and carcass characteristics of brangus and angus steers fed a finishing diet. Journal of Animal Science 65(SUPPL 1): 474

Merz, B.; Chen, X., 2005: A new species of Palloptera Fallen from China Diptera, Pallopteridae. The first species of Palloptera Fallen from China (Sichuan province, Mt. Emei), P. elegans n. sp., is described and illustrated. Its generic position and relationships within the genus are briefly discussed. Currently two extant species of the fam...