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Immunohistochemical identification of the receptor for urokinase plasminogen activator associated with fibrin deposition in normal and ectopic human placenta


, : Immunohistochemical identification of the receptor for urokinase plasminogen activator associated with fibrin deposition in normal and ectopic human placenta. Placenta. : 501-508,.

The receptor for urokinase plasminogen activator (uPAR) is a key molecule in cell surface-directed plasminogen activation. uPAR binds urokinase plasminogen activator (uPA) and thereby focuses plasminogen activation on the cell surface. Plasmin dissolves fibrin deposits and facilitates cell migration during tissue repair processes by degrading the extracellular matrix. During human implantation and placental development, plasmin is considered important for both trophoblast migration/invasion and for fibrin surveillance. This study examined the expression of uPAR in normal and ectopic human placentae by immunohistochemistry. In first and third trimester normal placentae as well as in tubal ectopic placental tissues, a high uPAR expression was seen in the trophoblast associated with deposits of fibrin-type fibrinoid. Extravillous trophoblast of the basal plate, of the cell islands, and of the cell columns was also positive for uPAR in the first trimester whereas at term the expression of the protein was decreased. Moreover, uPAR immunostaining was observed in decidual cells throughout normal gestation and in endometrial tissues of patients with ectopic pregnancies. These findings suggest that uPAR participates in placental development and in trophoblast invasion particularly in the first trimester of pregnancy and that uPAR is involved in repair mechanisms of the trophoblast and fibrin surveillance.

US$19.90

PMID: 9778123

DOI: 10.1016/s0143-4004(98)91043-8


Other references

LaHusen Richard G.; Iverson Richard M., 1988: Dynamic pore-pressure fluctuations in rapidly shearing granular media; field-scale experiments. Eos, Transactions, American Geophysical Union 69(44): 1195

John F.Bamrick, 1967: Resistance to American foulbrood in honey bees VI Spore germination in larvae of different ages. Germination varied when a constant dosage of Bacillus larvae spores was put into the larval food of honey-bee larvae (Apis mellifera) of different ages. Larvae were fed spores at 3, 21, and 45 hours of age. Samples of larvae were taken and fixed i...

Aroca Ruiz-Funes, J.M.; Martinez Lopez, A., 1969: Triple gallbladder. Revista Espanola de Las Enfermedades del Aparato Digestivo 29(3): 397-404

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Winston, D.C.; Spinale, F.G.; Crawford, F.A.; Schulte, B.A., 1990: Immunocytochemical and enzyme histochemical localization of Na+,K(+)-ATPase in normal and ischemic porcine myocardium. Na+,K(+)-ATPase is involved in generating transmembrane ion gradients and the associated potential difference necessary for contraction of cardiac myocytes. It is possible that changes in the activity or membrane content of this enzyme may occur u...

Hutchison, F.; Wai, C.M.; Jernegan, M.; Hicks, W.; Long, R., 1979: Distribution of cadmium, lead and zinc in soil around two phosphate processing plants in Pocatello, Idaho. On the windward and leeward sides, the concentrations of Cd, Pb and Zn in the surface soil varied with distance from the factories. The distribution pattern of the three metals was similar, but the Cd concentrations were higher than those of Pb an...

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Cahill, S.L.; Benotti, P.N., 1991: Catheter infection control in parenteral nutrition. Catheter sepsis rates related to total parenteral nutrition are variable and depend on several patient-specific factors. These factors include the presence of immunosuppression or critical illness, the use of multiple intravascular catheters, and...

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Przystalski A., 1986: The structure and dimensions of the alimentary canal in postembryonic development of the great tit parus major l. Studies were carried out of the changes in the length, the outer diameter, and the outer and inner surface area of the alimentary canal in the course of four development stages (I-IV) of 1.5, 3.0, 7.5, 15.0 - gram nestlings and adult individuals o...