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Immunohistochemical investigation of nasopharyngeal carcinoma using keratin, EMA, laminin, fibronectin, collagen type IV, laminin receptor, and laminin/collagen receptor antibodies

, : Immunohistochemical investigation of nasopharyngeal carcinoma using keratin, EMA, laminin, fibronectin, collagen type IV, laminin receptor, and laminin/collagen receptor antibodies. Acta Medica Nagasakiensia 38(2-4): 182-185

Immunohistochemical investigation was carried out to examine the characteristics of nasopharyngeal carcinoma (NPC) using 12 biopsy cases obtained from southern China. These cases were divided into three groups according to their predominant pattern associated with the cell and the tissue differentiation using the World Health Organization (WHO) classification as follows: (i) 4 cases with squamous cell carcinoma, (ii) 4 cases with differentiated nonkeratinizing carcinoma, (iii) 4 cases with undifferentiated carcinoma. These three types of NPC cases were reacted with keratin and epithelial membrane antigen (EMA). All neoplastic tissues were stained with keratin stronger than EMA. Squamous cell carcinoma and differentiated non-keratinizing carcinoma cases were diffusely stained strongly positive by immunoperoxidase for keratin. On the other hand, most of undifferentiated carcinoma cases were weakly or negatively reacted with keratin immunohistochemistry, and a part of tumor cytoplasms were stained strongly positive by keratin immunoreaction. For EMA immunoperoxidase method, squamous cell carcinoma cases were diffusely positive and most of differentiated non-keratinizing carcinoma and undifferentiated carcinoma cases were partly positive. However, none of NPC cases reacted with immunoreactivity for laminin 200, laminin 400, fibronectin, collagen, laminin receptor, and laminin/collagen receptor. Therefore, immunohistochemical characteristics of NPC showed epithelial cell origin, arising from squamous cells in nasopharynx.


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