+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical localisation of stem cell factor (SCF) with comparison of its receptor c-Kit proto-oncogene product (c-KIT) in melanocytic tumours

, : Immunohistochemical localisation of stem cell factor (SCF) with comparison of its receptor c-Kit proto-oncogene product (c-KIT) in melanocytic tumours. Virchows Archiv 427(3): 283-288

In order to characterise the distribution and role of stem cell factor (SCF), a recently-reported growth factor for normal melanocytes, we carried out an immunohistochemical study on benign and malignant melanocytic tumours with a comparison with the presence of its receptor c-Kit proto-oncogene product (c-KIT). In normal skin, SCF was mainly observed in endothelial cells of blood vessels but not frequently in basal melanocytes, whereas c-KIT was predominantly localised in tissue mast cells. In benign neoplastic melanocytes (common melanocytic naevi), localisation of SCF and c-KIT was complementary: SCF was mostly found in dermal naevus cells while c-KIT was revealed in epidermal naevus cells, although the expression of the latter antigen was not frequent. Malignant melanoma cells showed less frequent expression of these antigens than those in benign lesions. Of five cultured melanoma cell lines, SCF was observed in only one, and c-KIT was not found in any melanoma cells. No quantitative or qualitative alterations assessed by Western blot analysis were induced in the presence of phenotypic modifiers (sodium butyrate and HMBA). Present data suggest that loss of SCF expression in neoplastic melanocytes is commonly associated with malignant transformation of pigment cells rather than loss of its receptor c-KIT.


PMID: 7496598

DOI: 10.1007/bf00203396

Other references

Petersen, W.F., 1942: Drug sensitivity and the me-teorologic environment. A series of illustrative case records demonstrate the close integration that exists between the meteoro-logic environment and the condition of the individual as it is reflected in changing susceptibility to drug intoxication. The author cautions t...

Olfson, M., 1988: Lithium-responsive schizophrenia and rheumatoid arthritis. American Journal of Psychiatry 145(11): 1478-1479

Wilson, D.B., 1974: Proliferation in the neural tube of the splotch (Sp) mutant mouse. Journal of Comparative Neurology 154(3): 249-255

Baqain, Z.H.; Sawair, F.A.; Tamimi, Z.; Bsoul, N.; A.E.wan, G.; Almasad, J.K.; Abbadi, A.A., 2010: Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital. We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH). Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were ex...

Turgeon, P.; Turgeon, V.; Gourdeau, M.; Dubois, J.; Lamothe, F., 1994: Longitudinal study of susceptibilities of species of the Bacteroides fragilis group to five antimicrobial agents in three medical centers. A total of 579 clinical isolates of the Bacteroides fragilis group collected from three Canadian hospitals were tested for susceptibility to five antimicrobial agents by using an agar dilution method. During the 4-year survey, isolates from intra-...

Echenique-Guzman, E., 1937: Modification in Viruses Cultivated on Fertile Hens' Eggs. Connexion between Cow Pox and Fowl Pox. II. Naturally occurring vaccinia and fowl pox viruses are distinct immunologically and produce different histological reactions. Culture of vaccinia virus on the chorio-allantoic membrane of eggs resulted in slight variation of the mammalian virus...

Bhanja, P.; Mishra, S.; Manna, K.; Mallick, A.; Das Saha, K.; Bhaumik, A., 2017: Covalent Organic Framework Material Bearing Phloroglucinol Building Units as a Potent Anticancer Agent. Covalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticanc...

Arto, T.; Fernández, P.; Fañanás, F.J.; Rodríguez, Félix., 2016: Complex chromene derivatives through a silver-catalysed cascade reaction of simple o-alkynylsalicylaldehydes and alkenes. NlmCategory="UNASSIGNED">The silver-catalysed reaction of simple ortho-alkynylsalicylaldehydes and alkenes gives complex benzo[de]chromenyl ketones through an unusual cascade process where the starting ortho-alkynylsalicylaldehyde beh...

Ruef, J.; Bode, C.; Runge, M.S., 1997: Effects of fluid shear stress on atherogenesis and hemostasis. Fibrinolysis & Proteolysis 11(SUPPL 2): 159-164

Mehta, S.S.; Siegler, E.L.; Henderson, C.R.; Reid, M.Carrington., 2011: Acute pain management in hospitalized patients with cognitive impairment: a study of provider practices and treatment outcomes. Despite new guidelines and nationally mandated regular assessments, managing pain in cognitively impaired patients remains a complex and challenging task. Numerous studies have focused on assessing pain in this population; however, studies of trea...