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Immunohistochemical localization of GABA-A receptors in the scotopic pathway of the cat retina


, : Immunohistochemical localization of GABA-A receptors in the scotopic pathway of the cat retina. Cell & Tissue Research. 274(2): 267-277

The distribution of GABA-A receptors in the inner plexiform layer of cat retina was studied using monoclonal antibodies against the beta-2/beta-3 subunits. A dense band of receptor labeling was found in the inner region of the inner plexiform layer where the rod bipolar axons terminate. Three forms of evidence indicate that the GABA-A receptor labeling is on the indoleamine-accumulating, GABAergic amacrine cell that is synaptically interconnected with the rod bipolar cell terminal. (1) Electron microscopy showed that the anti-GABA-A receptor antibody (62-3G1) labeled profiles that were post-synaptic to rod bipolar axons and made reciprocal synapses. (2) Indoleamine uptake (and the subsequent autofluorescence) combined with GABA-A receptor immunohistochemistry showed co-localization of the two markers in half of the receptor-positive amacrine cells. (3) Double labeling demonstrated that half of the receptor-positive somata also contained GABA. These results indicate that a GABAergic amacrine cell interconnected with the rod bipolar cell, most likely the so-called A17 amacrine cell, itself bears GABA-A receptors.

US$19.90

PMID: 8269478

DOI: 10.1007/bf00318746


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