+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunohistochemical localization of Mcl-1 and bcl-2 proteins in thymic epithelial tumours

, : Immunohistochemical localization of Mcl-1 and bcl-2 proteins in thymic epithelial tumours. Histopathology (oxford). 29(6): 541-547

Mcl-1 protein is a new member of the bcl-2 protein family. It is believed to be a blocker of apoptosis but might be different from bcl-2 in the control of apoptosis. Using immunostaining of formalin-fixed, paraffin-embedded sections, we investigated the expression of Mcl-1 in 42 thymic epithelial tumours: three medullary thymomas, five mixed thymomas, seven cortical thymomas, eight well-differentiated thymic carcinomas, 14 squamous cell carcinomas, four lymphoepithelioma-like carcinomas and one undifferentiated carcinoma, bcl-2 immunocytochemical localization was also performed for comparison. High-grade thymic carcinomas, especially squamous cell carcinomas, revealed more intense Mcl-1 immunoreactivity as compared to other subtypes (P < 0.001). In cases that co-expressed Mcl-1 and bcl-2, the less differentiated cells had more intense expression of bcl-2, while the more differentiated cells displayed stronger Mcl-1 immunoreactivity. The differential expression of Mcl-1 and bcl-2 in neoplastic cells provides evidence that these proteins may play different roles in the processes of programmed cell death in thymic neoplasms. The finding that thymic carcinomas have stronger immunoreactivity for Mcl-1 indicates that this protein could be a useful marker to differentiate aggressive thymic epithelial tumours from indolent ones.


PMID: 8971561

DOI: 10.1046/j.1365-2559.1996.d01-540.x

Other references

The H.N.; Stadlin M.; D.G.andi P., 1985: The antenatal ultrasound diagnosis of fetoplacental edema. Ultrasound in becoming more and more important in the routine care of antenatal patients. It makes it possible to diagnose a certain number of fetal abnormalities and in particular fetoplacental oedema whether it is caused by immunological or othe...

Zeferos, N.; Digenis, G.E.; Christophoraki, M.; Alexopoulos, I.; Kostakis, A.; Gyftaki, H.; Moulopoulos, S., 1991: Tumor markers in patients undergoing hemodialysis or kidney transplantation. The following tumor markers, AFP, CEA, CA 19-9, CA-125 and CA 15-3 were studied in 50 healthy volunteers (group A), in 23 patients on chronic hemodialysis (group B) and in 30 successfully transplanted individuals (group C) who did not present any...

Sasaki, S.; Iwata, M., 2007: Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis. Little information is available about morphologic changes of mitochondria in sporadic amyotrophic lateral sclerosis (ALS). We examined the anterior horns of the lumbar spinal cord in 14 patients with sporadic ALS and 15 age-matched controls by el...

Hardy, R.R.; Hayakawa, K.; Haaijman, J.; Herzenberg, L.A., 1982: B-cell subpopulations identifiable by two-color fluorescence analysis using a dual-laser FACS. Annals of the New York Academy of Sciences 399: 112-121

Sulkhanishvili, V.A., 2007: Using plaferon in patients with nephrolithiasis of the only kidney. We have studied the influence of the Plaferon on the stimulation of restoration of a kidney function in patients with nephrolithiasis of the only kidney. The researches were performed in 42 patients with nephrolithiasis of the only kidney (control...

Wang, Y.; Wang, D.; Wu, J.; Wang, B.; Gao, X.; Wang, L.; Ma, H., 2015: Cinnabar-induced subchronic renal injury is associated with increased apoptosis in rats. The aim of this study was to explore the role of apoptosis in cinnabar-induced renal injury in rats. To test this role, rats were dosed orally with cinnabar (1 g/kg/day) for 8 weeks or 12 weeks, and the control rats were treated with 5% carboxym...

Meyer, K.; Kirkpatrick, M., 2004: Restricted maximum likelihood estimation of genetic principal components and smoothed covariance matrices. Principal component analysis is a widely used 'dimension reduction' technique, albeit generally at a phenotypic level. It is shown that we can estimate genetic principal components directly through a simple reparameterisation of the usua...

Tamura, E.; Honma, Y., 1970: Histological changes in the organs and tissues of the gobiid fishes throughout the life-span. 3. Hemopoietic organs in the Ice-goby, Leucopsarion petersi Hilgendorf. Bull. Jap. Soc. scient. Fish.: 36: 661-669,2 pis

Eriksen, H.M., 1977: Exeperimental studies on clinical aspects of composite resins. Den Norske Tannlaegeforenings Tidende 87(8): 362-370

Wu, W.; Platoshyn, O.; Firth, A.L.; Yuan, J.X-J., 2007: Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Acute hypoxia causes pulmonary vasoconstriction and coronary vasodilation. The divergent effects of hypoxia on pulmonary and coronary vascular smooth muscle cells suggest that the mechanisms involved in oxygen sensing and downstream effectors are...