geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Improved oocyte quality is obtained with follicle stimulating hormone alone than with follicle stimulating hormone/human menopausal gonadotrophin combination


, : Improved oocyte quality is obtained with follicle stimulating hormone alone than with follicle stimulating hormone/human menopausal gonadotrophin combination. Human Reproduction 12(9): 1886-1889

The aim of this study was to compare the efficacy of pure follicle stimulating hormone (FSH) with that of FSH/human menopausal gonadotrophin (HMG) combination in downregulated cycles. A total of 357 patients was evaluated retrospectively. Sixty percent of patients in the FSH group and 55% in the FSH/HMG group were new; the others were repeat patients. Ovulation was suppressed with leuprolide acetate in all patients, followed by either FSH (n = 218) or FSH/HMG (n = 119). There was no difference in patients' age, infertility factors, number of ampoules used, length of stimulation, oestradiol levels on day of human chorionic gonadotrophin (HCG) administration, number of oocytes recovered or the number of embryos transferred. Also, nuclear maturity at aspiration and fertilization rates were not different between the two groups. FSH stimulation resulted in a significantly higher percentage of mature oocytes that showed the typical 'mature' morphological characteristics (P < 0.0001). The clinical pregnancy rates per transfer were 40 and 28% in patients stimulated with pure FSH and FSH/HMG respectively (P < 0.05). The significantly higher number of immature oocytes matured in vitro in the FSH/HMG group (P = 0.001) suggests a possible effect on in-vitro maturation, due to luteinizing hormone present in HMG. The difference in mature oocyte quality may be an important determinant in the higher pregnancy rates for the FSH-stimulated patients.

US$19.90

PMID: 9363700

DOI: 10.1093/humrep/12.9.1886


Other references

Schwimmer, S., 1957: Phosphorylase inhibitor in potato: separation from activator and possible relation to chlorogenic acid. Nature 180(4577): 149-150

Mosebach, E., 1939: Von gesellig lebenden Schmetterlingsraupen. Natur und Volk Frankfurt a M: 69: 494-501

Chapman C.R., 1981: A theoretical analysis of discriminant performance related to pain. Pain. 1: S149

Cocking, I.T.; Winstanley, T.G., 2003: Screening for urinary tract infection with the Mastascan Elite. Mastascan Elite urine screen (MUS) is compared to a conventional method to determine significant growth of urinary pathogens and determine identification and susceptibility. MUS can detect at least 10(3) colony-forming units (cfu)/mL of commonly i...

Rungsung, I.; Ramaswamy, A., 2016: Insights into the structural dynamics of Liver kinase B1 (LKB1) by the binding of STe20 Related Adapterα (STRADα) and Mouse protein 25α (MO25α) co-activators. NlmCategory="UNASSIGNED">LKB1, the tumour suppressor, is found mutated in Peutz-Jeghers syndrome (PJS). The LKB1 is a serine-threonine kinase protein that is allosterically activated by the binding of STRADα and MO25α without phosph...

Thompson, W.R., 1922: On the Taxonomic Value of Larval Characters in Tachinid Parasites (Dipt.). Proceedings of the Entomological Society of Washington, 24: 85-93

Carnovale, C.E.; Marinelli, R.A.; Rodriguez Garay, E.A., 1987: Toxic effect of streptozotocin on the biliary secretion of nicotinamide-treated rats. The effect of streptozotocin (SZ) on bile flow (BF) and on protein and lipid biliary outputs were studied in rats with bile fistula. SZ was given i.v. as a single dose (50 mg/kg body wt.). Nicotinamide was administrated (500 mg/kg body wt., i.p.)...

Dunbar J.M.; Dean F.; Ellis J., 1979: Depression and anxiety in a primary care hypertensive population. Preventive Medicine 8(2): 153

Bruton A.M.; Schwarz Klaus Peter; Skaloud J., 2000: The use of wavelets for the analysis and de-noising of kinematic geodetic measurements. International Association of Geodesy Symposia 121: 227-232

Harada, H., 1958: Effects of soil-nutrient levels on the growth and nutrient uptake of forest seedlings. II. Interaction effects of nitrogen and phosphorus supply on growth of, and nutrient uptake by, Kara-matsu (Larix Kaempferi Sarg.) 1 + 0 seedlings.. Various levels of N and P were supplied to seedlings. Where N was omitted the leaves showed N-deficiency symptoms regardless of P level. Omission of P caused leaf symptoms which were greater with higher N levels. Neither N nor P applied alone had...