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Individualizing drug dosage regimens: roles of population pharmacokinetic and dynamic models, Bayesian fitting, and adaptive control


, : Individualizing drug dosage regimens: roles of population pharmacokinetic and dynamic models, Bayesian fitting, and adaptive control. Therapeutic Drug Monitoring 15(5): 380-393

The role of population pharmacokinetic modeling is to store experience with drug behavior. The behavior of the model is then correlated with the clinical behavior of the patients studied, permitting selection of a specific serum level therapeutic goal that is based on each individual patient's need for the drug and on the risk of adverse reactions, both of which must be considered. A dosage regimen is then computed to achieve that goal with maximum precision. The patient should not run a greater risk of toxicity than is justified, and should obtain the maximum possible benefit within the acceptable risk. The regimen is given and the patient monitored.

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PMID: 8249044


Other references

Rajpert-D.M.yts, E.; Lauke, H.; Skakkebaek, N.E., 1999: In vitro survival of human neoplastic germ cells. Advances in Experimental Medicine and Biology 444: 59-65; Discussion 65-6

Jenner, R.E.; Howard, E.R., 1975: Unsaturated monohydroxy bile acids as a cause of idiopathic obstructive cholangiopathy. It is proposed that some cases of biliary atresia and neonatal hepatitis may be initiated by an adverse effect of unsaturated monohydroxy bile acids on the fetal and infantile hepatobiliary system. The hypothesis is founded on morphological observ...

Silverstein, R.; Johnson, D.C., 2003: Endogenous versus exogenous glucocorticoid responses to experimental bacterial sepsis. Although lack of adrenals dramatically reduces resistance against sepsis generally, the value of glucocorticoid levels above those normally produced by stress remains controversial. An early and long-held concept is that glucocorticoid protection...

Stafford, E.S.; Schnaufer, L., 1964: An Investigation In Dogs Of Gastrojejunal Ulceration Subsequent To A New Method Of Duodenal Stimulation. Annals of Surgery 159: 802-806

Christianson, S.A.; Nilsson, L.G.; Mjörndal, T.; Perris, C.; Tjellden, G., 1986: Psychological versus physiological determinants of emotional arousal and its relationship to laboratory induced amnesia. Scandinavian Journal of Psychology 27(4): 300-310

Buchanan Bollig I.C., 1984: Circadian rhythms in kalanchoe blossfeldiana effects of irradiance and temperature on gas exchange and carbon metabolism. Gas exchange in K. blossfeldiana [a crassulacean acid metabolism plant] shows a circadian rhythm in net CO2 uptake and transpiration when measured under low and medium irradiances. The period length varies between 21.4 h at 60 W m-2 and 24.0 h at...

Furch, B.; Scholtz, A.L.; Leeb, W.R., 1982: Isolation and frequency conversion properties of acoustooptic modulators. Analysis shows that the isolation inherent in acoustooptic modulators is impaired if the acoustic wave is partially retroreflected. This effect generates additional spectral components in both the deflected and the re-troreflected light beam. The...

Krol, E.; Becker, A., 2012: ppGpp in Sinorhizobium meliloti: biosynthesis in response to sudden nutritional downshifts and modulation of the transcriptome. Sinorhizobium meliloti Rm2011 responds to sudden shifts to nitrogen or carbon starvation conditions by an accumulation of the stringent response alarmone ppGpp and remodelling of the transcriptome. The gene product of relA, Rel(Sm) , responsible f...

Seydel, Ch, 1927: Le papillon des citronniers. Notes on the biology of Papilio demodocus Esp. in Africa. Description of the different life stages, with figures of larva, chrysalis, adult [male] and [female].

Johnson, A.P.; Parlow, J.L.; Whitehead, M.; Xu, J.; Rohland, S.; Milne, B., 2016: Body Mass Index, Outcomes, and Mortality Following Cardiac Surgery in Ontario, Canada. The "obesity paradox" reflects an observed relationship between obesity and decreased morbidity and mortality, suggesting improved health outcomes for obese individuals. Studies examining the relationship between high body mass index (BM...