geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats


, : Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia. 37(12): 1202-1208

Intracerebroventricular neuropeptide Y (NPY) administration to normal rats for 7 days produced a sustained, threefold increase in food intake. resulting in a body weight gain of more than 40 g. Basal plasma insulin and triglyceride levels were increased in NPY-treated compared to vehicle-infused rats by about four- and two-fold. respectively. The glucose utilization index of white adipose tissue, measured by the labelled 2-deoxy-D-glucose technique was four times higher in NPY-treated rats compared to controls. This change was accompanied by an increase in the insulin responsive glucose transporter protein (GLUT 4). In marked contrast, muscle glucose utilization was decreased in NPY-treated compared to vehicle-infused animals. This change was accompanied by an increase in triglyceride content. When NPY-treated rats were prevented from overeating, there was no decrease in muscle glucose uptake, nor was there an increase in muscle triglyceride content. This suggests that muscle insulin resistance of ad libitum-fed NPY-treated rats is due to a glucose-fatty acid (Randle) cycle. When intracerebroventricular NPY administration was stopped and rats kept without any treatment for 7 additional days, all the abnormalities brought about by the neuropeptide were normalized. A tonic central effect of NPY is therefore needed to elicit and maintain most of the hormonal and metabolic abnormalities observed in the present study. Such abnormalities are analogous to those seen in the dynamic phase of obesity syndromes in which high hypothalamic NPY levels have been reported.

US$19.90

PMID: 7895949

DOI: 10.1007/bf00399793


Other references

Meißner, C.; Meyer, F.; Ridwelski, K., 2015: Magdeburg's surgical talks 2013 and annual meeting of the institute for quality assurance in operative medicine- symposium report. Zentralblatt für Chirurgie 139(5): E15-E18

Smith L.A., 1986: A new species of hydrophis serpentes hydrophiidae from northwest australian waters. A new species of sea snake (Hydrophis geometricus) from northwest Australian waters is described. It is compared with H. macdowelli Kharin and H. ocellatus Gray.

Pignon J P.; Hill C., 1991: Estimation of alcohol related deaths in france 1985. The number of deaths attributable to alcohol in France during 1985 has been estimated from national death statistics, and from records attributable risks for each disease related to alcohol. The attributable risks for alcohol by sex and by disease...

Stovitz, S.D., 2011: The pyramid of sports medicine and child health. British Journal of Sports Medicine 44(1): 4-7

Pinto-Cisternas, J., 1977: Human genetics in dentistry: superfluous or fundamental?. Acta Odontologica Venezolana 15(3): 50-71

Parr M.B.; Tung H.N.; Parr E.L., 1986: Permeability of the primary decidual zone an ultrastructural tracer study. Biology of Reproduction 34(SUPPL 1): 103

Eckhoff, Ga, 1976: Prescription writing for the veterinarian. Iowa State University veterinarian: 8 (2) 50-53

Jaken, S.; Chapline, C.; Li, Y.; Mousseau, B.W., 1997: Disrupted PKC signaling in transformed cells. Proceedings of the American Association for Cancer Research Annual Meeting 38(0): 502

Xue Wanjun, 1982: On the ages and sedimentation environments of the Beihai Formation. Pages (81-8

Filipek Lorraine H., 1986: Influence of iron and manganese on the chemical partitioning of copper, zinc, and chromium during early diagenesis in outer continental-shelf sediments from the Gulf of Mexico. U S