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Induction of Apg-1, a member of the heat shock protein 110 family, following transient forebrain ischemia in the rat brain

, : Induction of Apg-1, a member of the heat shock protein 110 family, following transient forebrain ischemia in the rat brain. Biochemical and Biophysical Research Communications 247(3): 796-801

Apg-1 (Osp94) and apg-2 belong to the heat shock protein (hsp) 110 family. In mouse somatic cells the apg-1 and hsp105/110 transcripts are inducible by a 32 degrees C to 39 degrees C heat shock, while apg-2 is not heat-inducible. Since ischemia is known to induce expression of hsp70, its effect on expression of apg-1 was assessed by using the 20-min forebrain ischemia model of the rat. In the cerebral cortex, Northern blot analysis and in situ hybridization histochemistry demonstrated an increased expression in neuronal cells of apg-1 transcripts 3 h after the onset of reperfusion, with a peak at 12 h, followed by a decline. In the hippocampus, the level was increased at 3 h, remained constant until 24 h, and then declined. Transcript levels of apg-2 as well as hsp 105 were also increased under the present conditions, indicating that the expression of apg-2 was differentially regulated in response to heat and ischemic stresses. The induction kinetics of hsp 105, but neither apg-2 nor hsp 70, were identical to those of apg-1. These results demonstrated that brain ischemia/reperfusion induced expression of each member of the hsp 110 family, although the regulatory mechanisms may not be the same. They also suggest a significant role of apg-1 in both the ischemic- and heat-stress responses and in the normal functioning of the non-stressed neuronal cells.


PMID: 9647773

DOI: 10.1006/bbrc.1998.8894

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Streetly, M.; Kazmi, M.; Schey, S., 2002: Intermediate Dose Melphalan for De Novo Multiple Myeloma Gives High Complete Response Rate and Durable Long Term Survival. The use of thalidomide in refractory myeloma has led to improvements in response and survival. However, in de novo myeloma complete remission remains the goal because this leads to a survival advantage. This can be achieved using combination chemo...

Pannese, E., 1958: Glial architecture of the white substance of the vertebrate spinal cord. 2. Morphogenetic findings; general deductions. Zeitschrift für Anatomie und Entwicklungsgeschichte 120(4): 279-301

Cain, D.F.; Dekaban, A.S., 1971: Correlation of brain proteins in degenerative diseases, encephalitis, gliomas and focal epilepsy. Transactions of the American Neurological Association 96: 215-216

Masarik J.; Nishizumi K.; Welten K.C., 2007: Spallation and neutron-capture produced cosmogenic nuclides in aubrites. Meteoritics and Planetary Science 42, Supplement: A98

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Padwick, G.Watts, 1940: The genus Fusarium, V Fusarium udum Butler, Fusarium vasinfectum Atk and F lateritium Nees var uncinatum Wr. The authors studied in systematic manner the morph. and cultural characteristics of several isolates of Fusarium capable of causing wilt of cotton (Gossypium sp.), pigeon-pea (Cajanus cajan) and sunn-hemp (Crotalaria juncea). These were grown on 2...

Partidario, Maria R., 1999: Strategic environmental assessment; principles and potential. Petts, J. Handbook Of Environmental Impact Assessment, Vol. 1. Environmental Impact Assessment: Process, Methods And Potential. 60-73

Kulikova N.I.; Fedulina V.N., 1987: The response of the golden mullet liza aurata risso to pituitary injections kept under different conditions. The effectiveness of pituitary injections in stimulation of spermiation reaction, oocyte maturation and ovulation in reproducers of golden mullet kept under different conditions of salinity and temperature has been studied. It has been ascertained...

Jankov, T.; Karahoda, S.; Lika, S., 1977: Esthetic harmony from the prosthetic viewpoint. Stomatoloski Glasnik Srbije 24(1): 11-16