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Influence of a radioprotector WR-638 on the lymphoid compartment of the irradiated rat thymus: a flow cytometric analysis


, : Influence of a radioprotector WR-638 on the lymphoid compartment of the irradiated rat thymus: a flow cytometric analysis. International Journal of Radiation Biology 66(2): 143-150

The T cell composition of the thymus of X-ray irradiated (3-5 Gy) Wistar rat protected with WR-638 was analyzed by flow cytometry using monoclonal antibodies directed to the Thy 1.1, CD43, CD2, CD5, CD4, CD8 and class I and II MHC antigens. It was shown that this dose of X-rays caused cyclic changes in thymic cellularity manifested as: primary involution (until day 2), primary regeneration (from days 2 to 14), secondary involution (from days 14 to 21) and secondary regeneration (from days 21 to 30). WR-638 reduced the magnitude of thymocyte depletion in the primary involutive phase of the irradiated thymi, primarily as a result of protection of Thy 1.1-high+ CD2-low+ CD5-high+ CD4+ CD8+ class I antigen-high+ subpopulations of thymocytes. In the early regenerative phase, WR-638 accelerated the regeneration of CD4-CD8- and CD4-CD8+ thymocyte subsets, followed by subsequent increase of CD4+CD8+ and CD4+CD8- thymocyte subsets. Secondary involutive and regenerative phases in protected animals were characterized by higher absolute cell number of almost all thymocyte subpopulations in comparison with those in irradiated, non-protected animals.

US$19.90

PMID: 8089624

DOI: 10.1080/09553009414551041


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Luker, K.E.; Luker, G.D., 2010: Real-time bioluminescence imaging of viral pathogenesis. Mouse models are used commonly to study viral infection and define viral and host determinants of infection and disease morbidity. Conventional studies of viral infection in mice rely upon euthanizing cohorts of animals at multiple time points to...

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