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Intensity of lipid peroxidation processes and activities of NADP-dependent dehydrogenases and proteases in the brain of rats after repeated injections of insulin


, : Intensity of lipid peroxidation processes and activities of NADP-dependent dehydrogenases and proteases in the brain of rats after repeated injections of insulin. Problemy Endokrinologii 44(3): 35-38, May-June

The rate of accumulation of malonic dialdehyde was increased, the activities of superoxide dismutase, NADP-dependent glucose-6-phosphate, malate, isocitrate dehydrogenases and glutathione reductase decreased, and the levels of diene conjugates decreased in the hemispheres and brain stem of rats subjected to 7-9 hypoglycemic comas. The activities of neutral and acid proteases were increased in the stem structures. The detected changes indicate an oxidative stress developing in the nerve tissue after repeated hypoglycemic exposures. Such changes appear after glucose arrest of hypoglycemic coma and can be important in the pathogenesis of posthypoglycemic encephalopathy.

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