geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intravesical mitomycin C and doxorubicin sequential therapy for carcinoma in situ of the bladder: a longer followup result


, : Intravesical mitomycin C and doxorubicin sequential therapy for carcinoma in situ of the bladder: a longer followup result. Journal of Urology 151(1): 27-30

A total of 43 patients with carcinoma in situ of the bladder (primary in 26 and secondary in 17) who underwent intravesical mitomycin C and doxorubicin sequential therapy for 2 multicenter studies were followed for a median period of 45 months (range 10 to 84). Of the patients 32 (74%) achieved complete response after induction therapy and underwent maintenance therapy with either mitomycin C plus doxorubicin, mitomycin C alone or observation only. Of the complete responders 13 (41%) had a local recurrence, and subsequent repeat intravesical mitomycin C and doxorubicin sequential therapy as well as bacillus Calmette-Guerin was effective in a significant proportion (75% or greater). The maintenance therapy did not have a favorable effect on the recurrence rate. In 8 patients (19%) (3 of 32 complete responders and 5 of 11 nonresponders) progression developed, including invasive cancers in 4, metastatic disease in 2 and both conditions in 2. Initial complete responders had a significantly higher progression-free rate than initial nonresponders, although there was no difference in the sites of progression between them. At the last follow-up 35 patients (81%) remained free of disease with 31 (72%) having a normally functioning bladder. According to these results, intravesical mitomycin C and doxorubicin sequential therapy appears to be applicable as initial treatment for carcinoma in situ of the bladder.

US$29.90

PMID: 8254827


Other references

Shearer B.L.; Zadoks J.C., 1972: The latent period of septoria nodorum in wheat part 1 the effect of temperature and moisture treatments under controlled conditions. Netherlands Journal of Plant Pathology 78(6): 231-241

Hural, J.A.; Kwan, M.; Henkel, G.; Hock, M.B.; Brown, M.A., 2000: An intron transcriptional enhancer element regulates IL-4 gene locus accessibility in mast cells. The cell type-specific expression of a gene is dependent on developmentally regulated modifications in chromatin structure that allow accessibility of basal and inducible transcription factors. In this study, we demonstrate that a cis-acting eleme...

Stokoe, W.J., 1958: The caterpillars of British moths including the eggs, chrysalids and food-plants. Edited and with special articles by G. H. T. Stovin. Second series Geometridae to Hepialidae, revised edn. Unknown

Dorn, C.R.; Silapanuntakul, R.; Angrick, E.J.; Shipman, L.D., 1993: Plasmid analysis of Salmonella enteritidis isolated from human gastroenteritis cases and from epidemiologically associated poultry flocks. Plasmid analysis of Salmonella enteritidis isolates from human gastroenteritis cases and from two commercial egg-producing poultry flocks was performed to determine if the poultry flocks were the source of the human infections. The plasmid profile...

Greene, S.M.; Hammett, A.L.; Shashi Kant, 2000: Non-timber forest products marketing systems and market players in southwest Virginia: crafts, medicinal and herbal, and specialty wood products. Non-timber forest products (NTFPs) are important in rural southwest Virginia, USA, as a source of household income. Marketing system of crafts, medicinal and herbal, and specialty wood products were studied using exploratory and qualitative resear...

Weston, M.C.; Chen, H.; Swann, J.W., 2012: Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. The mammalian target of rapamycin (mTOR) signaling pathway in neurons integrates a variety of extracellular signals to produce appropriate translational responses. mTOR signaling is hyperactive in neurological syndromes in both humans and mouse mo...

Swaak, A.J.; Groenwold, J.; Aarden, L.A.; Statius van Eps, L.W.; Feltkamp, E.W., 1982: Prognostic value of anti-dsDNA in SLE. In a prospective longitudinal study 130 patients with systemic lupus erythematosus (SLE) were studied at least monthly for a relationship between the anti-dsDNA levels and disease activity. We observed 13 patients who developed 15 periods of exace...

Vilenchuk E.A.; Dal' G.A., 1990: Lung surfactant system and respiratory mechanics in patients with acute postoperative respiratory insufficiency. Anesteziologiya i Reanimatologiya (1): 65-66

Bhutani, V.K.; Seiberlich, W.; Harris, K.; Grous, M.; Sivieri, E.M., 2000: Active versus passive hypercapnia in the ventilatory management of micropremies with RDS. Pediatric Research 47(4 Part 2): 389A, April

Meier, R.L., 1961: Explorations in the realm of organization theory. IV. The simulation of social organization. The study of various aspects of organization theory has been undertaken by this author in previous articles in Behavioral Science. In the January, 1958 issue, Models for Man and The Organization of Space were discussed, while in the July, 1959 iss...