geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Is there cross-refractoriness between phospholipase A-2 and the calcium ionophore A23187 in the stimulation of uterine prostaglandin production?


, : Is there cross-refractoriness between phospholipase A-2 and the calcium ionophore A23187 in the stimulation of uterine prostaglandin production?. Prostaglandins Leukotrienes & Essential Fatty Acids. 48(4): 327-330

Phospholipase (PL) A-2 increased the outputs of prostaglandin (PG) F-2 alpha, PGE-2 and 6-keto-PGF-1alpha from the mid-cycle guinea-pig uterus, but repeating the PLA-2 treatment 1 h later failed to increase uterine PG output. Similarly, A23187 increased PG output from the mid-cycle guinea-pig uterus, but repeating the A23187 treatment 1 h later produced a very much smaller stimulatory effect. Thus the guinea-pig uterus showed complete refractoriness to PLA-2 and partial refractoriness to A23187, as regards the stimulation of uterine PG production, when the uterus is treated with the same compound after an interval of 1 h. However, when the mid-cycle guinea-pig uterus was treated with PLA-2 1 h after being treated with A23187, or was treated with A23187 1 h after being treated with PLA-2, the second compound produced a normal stimulation of PG output and was not affected, therefore, by treatment with the first compound. Consequently, there is no cross-refractoriness between PLA-2 and A23187 as regards their stimulatory effects on PG production by the guinea-pig uterus.

US$19.90

PMID: 8497494

DOI: 10.1016/0952-3278(93)90225-L


Other references

Kriz, J.; Jirák, D.; Girman, P.; Berková, Z.; Zacharovova, K.; Honsova, E.; Lodererova, A.; Hajek, M.; Saudek, F., 2005: Magnetic resonance imaging of pancreatic islets in tolerance and rejection. Background. We have recently described a magnetic resonance (MR) method for detection of rat pancreatic islets transplanted into the liver after labeling with superparamagnetic iron oxide nanoparticles. The aim of this work was to study whether th...

Baba, K., 1973: Dr. Horvath Andor 1913-1972. Soosiana, 1: 7-8

Yildirim, A.Erdem.; Divanlioglu, D.; Karaoglu, D.; Cetinalp, N.Eralp.; Belen, A.Deniz., 2016: Pure Endoscopic Endonasal Clipping of an Incidental Anterior Communicating Artery Aneurysm. Anterior communicating artery (AcoA) aneurysm is the most common form of intracranial aneurysm. It occurs rarely together with other intracranial lesion. Today, microsurgical techniques and endovascular methods are used in the treatment of these a...

Montagnes, R.J.an, S.; Bayer, R., J.; Vitt, D., H., 1993: Isozyme variation in the moss Meesia triquetra (Meesiacea). Isozyme variation in eight enzyme systems in plants from 15 fens from three regions (boreal, subarctic, and high arctic) indicate that the gene diversity of Meesia triquetra, at 0.151, and genetic identity values (0.80-1.00) between populations of...

Jougleux-Vie, C.; Duhin, E.; Deken, V.; Outteryck, O.; Vermersch, P.; Zéphir, Hélène., 2014: Does fatigue complaint reflect memory impairment in multiple sclerosis?. Background and Purpose. Fatigue and memory impairment are common symptoms in multiple sclerosis (MS) and both may interact with cognition. This can contribute to making a complaint misrepresentative of the objective disorder. We sought to determin...

Hazlewood, G.; Cho, K.; Dawson, R.; Munn, E., 1983: Subcellular fractionation of the gram negative rumen bacterium, Butyrivibrio S2, by protoplast formation, and localisation of lipolytic enzymes in the plasma membrane. Treatment of the anaerobic, gram negative general fatty acid auxotroph Butyrivibrio S2 with lysozyme in low molarity buffers resulted in the formation of protoplasts, some of which retained the original rod-shaped morphology of the organism. The p...

Stahl F.; Amendt P.; Doerner G., 1979: Total and free cortisol plasma levels in pre natal and post natal life. Endokrinologie 74(2): 243-246

Tanaka, T.; Takahashi, M.; Kusano, E.; Okamoto, H., 2007: Development and evaluation of an efficient cell-culture system for Hepatitis E virus. Using a faecal suspension with high load of Hepatitis E virus (HEV) (2.0 x 10(7) copies ml(-1), genotype 3), we developed an efficient cell-culture system for HEV in a hepatocarcinoma cell line (PLC/PRF/5). HEV progeny released in the culture med...

Mamula; von Zelewsky A.B.rk; Stoeckli-Evans; Neels; Bernardinelli, 2000: Predetermined chirality at metal centers of various coordination geometries: a chiral cleft ligand for tetrahedral (T-4), square-planar (SP-4), trigonal-bipyramidal (TB-5), square-pyramidal (SPY-5), and octahedral (OC-6) complexes. Two tetradentate bispinene-bipyridine type ligands, each with six stereogenic carbon centers, were synthesized from (-)-alpha-pinene. Their ability to predetermine chiral configurations at metal centers was studied. The two diastereoisomers, L1 an...

Price, M.N.; Hyde, J.Shibley., 2012: Perceived and observed maternal relationship quality predict sexual debut by age 15. Early sexual behaviors during adolescence have the potential to lead to unhealthy outcomes. This study explored the association between specific dimensions of maternal relationship quality and adolescent sexual debut by age 15. We hypothesized tha...