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Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children

, : Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatric Nephrology. 10(6): 709-711

The ability of the Schwartz formula (C-SCH) to estimate glomerular filtration rate (GFR) accurately was investigated in children with renal disease. 125Iodine-iothalamate clearance (C-IO) was used as the reference standard for measuring GFR. Data from 176 C-IO studies performed on 133 children (aged between 1 and 18 years) were compared with the simultaneous estimation of GFR by C-SCH. The overestimation of GFR by C-SCH was inversely proportional to the level of renal function. When C-IO was gt 90 ml/min per 1.73 m-2, C-SCH overestimated GFR by only 0.1% +- 3%, but when C-IO was ltoreq 15 ml/min per 1.73 m-2, C-SCH overestimated GFR by 164%+-42%. When renal function is normal or mildly reduced (GFR gt 50 ml/min per 1.73 m-2), C-SCH overestimated C-IO by only 10.3 +- 3.0%, compared with 90.3 +- 14.5% when renal function was moderately to severely curtailed (GFR ltoreq 50 ml/min per 1.73 m-2). We conclude that C-SCH is valid in predicting GFR only in children with normal renal function and mild insufficiency.


PMID: 8971885

DOI: 10.1007/s004670050195

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