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Long-term effects of inhaled nicotine


, : Long-term effects of inhaled nicotine. Life Sciences. 58(16): 1339-1346

Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.

US$19.90

PMID: 8614291

DOI: 10.1016/0024-3205(96)00100-2


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Yokoyama, Yusuke; Suga, Hisami; Esat, Tezer M.; Ohkouchi, Naohiko; Lambeck, Kurt; Graham, Russell W., 2008: Global icevolume changes during MIS 3 and 2 recorded in sea-level observations from western Pacific sites. Program and Abstracts - American Quaternary Association. Conference 20

Abdel Galil, F.A.; Mohammed, Z.A.y; Khaled, S.O.man; Abou E.M.gd, S.M., 2007: Harmony of seasonal abundance of Psammotermes hybostoma Desneux population (Isoptera: Rhinotermitidae) with some ambient environmental biotic and abiotic factors. The present work attempts to reveal the homogenous relationship between seasonal fluctuation of the sand termite Psammotermes hybostoma and some surrounding biotic factors represented by associated arthropods specially insects, in addition to abio...

Guenther, C.R., 1995: Con: early extubation after cardiac surgery does not decrease intensive care unit stay and cost. Journal of Cardiothoracic and Vascular Anesthesia 9(4): 465-467

Nowak, M.A.; May, R.M., 1991: Mathematical biology of HIV infections: antigenic variation and diversity threshold. Infection with the human immunodeficiency virus (HIV) results in severe damage to the immune system and consequent disease (AIDS) after a long and variable incubation period (on average 8-10 years). Why the incubation period should be so long is a...

Bieren, R.E., 1969: Tourette's disease: successful treatment. Journal of the South Carolina Medical Association 65(1): 7-8

Forni, C.; Mainard, O.; Melon, C.; Goguenheim, D.; Kerkerian-L.G.ff, L.; Salin, P., 2012: Portable microstimulator for chronic deep brain stimulation in freely moving rats. In the last decades, deep brain stimulation (DBS) has been widely used as a functional surgical strategy for the treatment of a variety of neurological and psychiatric disorders, including Parkinson's disease (PD), dystonia, epilepsy, depress...

Hinton, D.; Lantz, R.1; Birch, K1; Burrell, R., 1983: Quantitative morphologic studies of the lung following inhalation of bacterial endotoxin Causative factor in byssinosis, cotton bract. Proceedings Beltwide Cotton Production Research Conferences: th) 39-44

Caseiro, T., 1986: A review for nurses' aides ... some impressions in the confusion. Revue de L'infirmiere 36(10): 14-15

Asano, E.; Hasegawa, H.; Hyodo, T.; Ito, S.; Maeda, M.; Chen, D.; Takahashi, M.; Hamaguchi, M.; Senga, T., 2015: SHCBP1 is required for midbody organization and cytokinesis completion. The centralspindlin complex, which is composed of MKLP1 and MgcRacGAP, is one of the crucial factors involved in cytokinesis initiation. Centralspindlin is localized at the middle of the central spindle during anaphase and then concentrates at the...

Morady, F.; DiCarlo, L.; Winston, S.; Davis, J.C.; Scheinman, M.M., 1984: A prospective comparison of triple extrastimuli and left ventricular stimulation in studies of ventricular tachycardia induction. One hundred and one patients with sustained unimorphic ventricular tachycardia underwent programmed ventricular stimulation with one of two protocols. Fifty patients underwent programmed stimulation with protocol A, which consisted of burst overdr...