+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term follow-up of an EORTC randomized prospective trial comparing intravesical bacille Calmette-Guerin-RIVM and mitomycin C in superficial bladder cancer

, : Long-term follow-up of an EORTC randomized prospective trial comparing intravesical bacille Calmette-Guerin-RIVM and mitomycin C in superficial bladder cancer. Urology 52(3): 403-410, Sept

Objectives. To determine long-term efficacy of intravesical mitomycin C (MMC) versus bacille Calmette-Guerin (BCG) in patients with superficial bladder cancer with regard to recurrences and progression. Methods. Patients with superficial bladder cancer (pTa, pT1, pTis) were treated with intravesical MMC (30 mg, weekly for 4 weeks, and thereafter monthly for 5 months) or BCG (weekly for 6 weeks). Results. Three hundred forty-four patients were eligible (171 in the BCG group, 173 in the MMC group). The median follow-up was 7.2 years. Toxicity was not significantly different between the two treatment groups. Efficacy of the two treatment policies was similar with regard to tumor recurrence. With regard to progression to invasive disease, MMC was more effective than BCG in patients without carcinoma in situ (CIS) (P=0.006). Conclusions. We can confirm the conclusions of other studies that intravesical treatment with 30 mg of MMC remains an effective treatment option that can also be used in high-risk patients. Like others, we could not confirm that a 6-week course of BCG is more effective in the prevention of tumor progression. Of the 33 progression after intravesical therapy carries a poor prognosis. In this study the difference in toxicity patients with tumor progression after intravesical therapy, 20 died of bladder cancer, confirming that tumor between BCG and MMC was not significant. When comparing studies with MMC and BCG, differences in treatment schedule and/or patient selection should be kept in mind.


DOI: 10.1016/S0022-5347(05)69020-9

Other references

Litzow, M., A.; Piatt, J., F.; Abookire, A., A.; Robards, M., D., 2004: Energy density and variability in abundance of pigeon guillemot prey: support for the quality-variability trade-off hypothesis. 1. The quality-variability trade-off hypothesis predicts that (i) energy density (kJ g-1) and spatial-temporal variability in abundance are positively correlated in nearshore marine fishes; and (ii) prey selection by a nearshore piscivore, the pig...

Samaranayaka, A.G.P.; Wanasundara, J.P.D.; Pegg, R.B.; Shand, P.J., 2002: Off-flavor development of cooked-stored chicken meat Chemical, instrumental and sensorial assessment. Abstracts of Papers American Chemical Society 224(1-2): AGFD 88

Duntze, O.; Watermann, F.; Giani, L., 2005: Reconstruction of the paleo-environment and geopedogenesis of non-calcarous marshland soils (Eutric Gleysols) of Lower Saxony. The genesis of non-calcareous marshland soils is still controversial. For clarification, the palaeo-environments of two Eutric Gleysols from Lower Saxony, Germany, were reconstructed by using X-ray fluorescence spectroscopy, light microscopy, and...

Schulz, V.; Schmidt, W.; Schanbel, K.H.; Just, H.; Gladisch, W., 1976: Pulmonary gas exchange after myocardial infarction in the late period of recovery. II. Investigations during exercise. After myocardial infarction in the late period of recovery (13-25 months p. infarctum) pulmonary gas exchange in 23 patients was measured besides as hemodynamic parameters during exercise. The parameters take a course similar to that of subjects w...

Warnert, J., 2004: Conventionally bred papaya still possible, even in California. California agriculture e 58(2): 74

Wichansky E., 1969: Less well known mushrooms growing in winter or from the fall till the spring. Mykologicky Sbornik 46(1-2): 7-8

DeMarzo, A.P., 2011: Using impedance cardiography with postural change to stratify patients with hypertension. Early detection of cardiovascular disease in patients with hypertension could initiate appropriate treatment to control blood pressure and prevent the progression of cardiovascular disease. The goal of this study was to show how impedance cardiogr...

Leak L.V., 1974: Freeze fracture transmission electron microscopic and scanning electron microscopic studies on the normal lymph node. Anatomical Record 178(2): 399-400

Lucotte, Gerard, 2002: Frequencies of 32 base pair deletion of the (DELTA32) allele of the CCR5 HIV-1 co-receptor gene in Caucasians: A comparative analysis. The CCR5 gene encodes for the co-receptor for the major macrophage-tropics strains of human immunodeficiency virus (HIV-1), and a mutant allele of this gene (DELTA32) provide to homozygotes a strong resistance against infection by HIV. The frequen...

Rotmans J.P.; Van Dijk D.A.M., 1983: Detergent solubilization of antigens from the tegument of schistosoma mansoni. Tropical & Geographical Medicine 35(2): 204-205