+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term therapy with deferiprone

, : Long-term therapy with deferiprone. Acta Haematologica 95(1): 37-48

Data from several trials have provided direct and supportive evidence for the efficacy of deferiprone in the treatment of iron overload in thalassemia major. Deferiprone has been shown to induce sustained decreases in body iron to concentrations associated with survival free from the complications of iron overload in deferoxamine (DFO)-treated patients. Despite this evidence of efficacy, the risk of agranulocytosis mandates a careful evaluation in patients willing and able to use DFO. The incidence of agranulocytosis associated with deferiprone is under study in a prospective multicenter trial in Canada, Italy and the United States, under corporate sponsorship (Apotex Research, Canada). The results of this study should determine the risk associated with the use of this agent, and may provide the data required for an FDA decision regarding licensing of this agent for the treatment of iron overload, a goal supported by investigators worldwide.


PMID: 8604585

DOI: 10.1159/000203854

Other references

Alió, J., 2016: September consultation #8. Journal of Cataract and Refractive Surgery 41(9): 2030-2031

Perju, T.; Oltean, I., 2002: The pests of flowers, fruits and seeds of medicinal and aromatic plants. Some 33 species of insect pests were observed damaging the flowers, fruits and seeds of Romanian medicinal and aromatic plants belonging to 11 families, including Apiaceae, Asteraceae, Boraginaceae, Hypericaceae, Lamiaceae, Malvaceae, Papaveraceae...

Badawy, S.Z.; Anderson, G.H.; Shende, M.C.; Marshall, L., 1984: Development of acromegaly in a patient with prolactinemia: a case study. Fertility and Sterility 42(6): 926-928

Swanberg, Tim R., 1997: Movements of bull trout in the Clark Fork River System after transport upstream of Milltown Dam. Populations of bull trout in the Clark Fork River drainage of western Montana are small and fragmented by hydroelectric dams. The movements of four adult bull trout in this river were monitored by radiotelemetry after transport upstream of Milltow...

Hogarty, G.E.; Kornblith, S.J.; Greenwald, D.; DiBarry, A.L.; Cooley, S.; Flesher, S.; Reiss, D.; Carter, M.; Ulrich, R., 1995: Personal therapy: a disorder-relevant psychotherapy for schizophrenia. While the long-term care of ambulatory schizophrenia patients requires highly effective interpersonal treatment skills among clinicians, there is little evidence to support an empirically validated individual psychotherapy of schizophrenia. Person...

Wang C., 2004: Using the response of streams to earthquakes to study hydrologic processes. Eos, Transactions, American Geophysical Union 85(47, Suppl

Mbow, M.L.; Titus, R.G., 2000: The influence of skin Langerhans cells on the outcome of Leishmania major-specific T cell priming. FASEB Journal 14(6): A1030, April 20

Sattar, M.; Lane, M.E., 2016: Oral transmucosal delivery of naratriptan. NlmCategory="UNASSIGNED">Naratriptan (NAR) is currently used as the hydrochloride salt (NAR.HCl) for the treatment of migraine and is available in tablet dosage forms for oral administration. Buccal drug delivery offers a number of ad...

Politi L.; Cerulli N.; D'angelo A.R.; Scandurra R., 1989: Perfusion of uremic blood ultrafiltrate on uncoated charcoal. A granular uncoated charcoal removes from uremic blood ultrafiltrates many chemical species that are not removed by dialysis. Charcoal treatment dramatically improves the general condition of the patients and normalizes their blood pressure. To ob...

Mihovilovic, M.A., 1981: Leisure and tourism in Europe: an assessment. This article outlines the expansion of personal leisure time in absolute and relative terms and the subsequent increase in the volume of tourism. Research is required to produce meaningful assessment of the trends of tourism in Europe. Some data a...