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Low extracellular dopamine levels are maintained in the anoxic turtle (Trachemys scripta) striatum


, : Low extracellular dopamine levels are maintained in the anoxic turtle (Trachemys scripta) striatum. Journal of Cerebral Blood Flow and Metabolism 18(7): 803-807

The uncontrolled increase of extracellular dopamine (DA) has been implicated in the pathogenesis of hypoxic/ischemic damage in the mammalian brain. But unlike the harmful release of excitatory neurotransmitters such as glutamate and aspartate, which occurs on brain depolarization, excessive extracellular DA levels occur even with mild hypoxia in the mammalian brain. The purpose of this study was to determine whether hypoxia/anoxia provokes a similar increase in the anoxic tolerant turtle brain. Extracellular DA was measured in the striatum of the turtle using microdialysis followed by high-performance liquid chromatography analysis. Results show that extracellular DA was held to normoxic levels over 4 hours of anoxia. Treatment with the specific DA transport blocker GBR 12909 during anoxia resulted in a significant increase in DA to 236% over basal levels. The ability to maintain low striatal extracellular DA may be an important adaptation for anoxic survival in the turtle brain; a contributing factor is the continued functioning of DA uptake mechanisms during anoxia.

US$19.90

PMID: 9663509

DOI: 10.1097/00004647-199807000-00010


Other references

Kyttala, M.; Paavola, P.; Salonen, R.; Peltonen, L., 2000: Towards the gene defect causing Meckel syndrome. American Journal of Human Genetics 67(4 Supplement 2): 381, October

Vodianitskii, V.; Bykov, M.; Kaeantseva, L., 1980: Effect of the irrigation method on yields and economic efficiency of an apple orchard. Sadovodstvo vinogradarstvo i vinodelie Moldavii: (6) 22-24

V.V.Shiryaev, 1970: Mechanism of platelet participation in maintenance of resistance of vascular walls. Bulletin of Experimental Biology and Medicine 69(5): 530-531

Tedeschi F.; Crafa P.; Corradi A.; Cabassi E., 1991: Neuro axonal dendrite and gliocyte dystrophy in natural scrapie ultrastructural findings. European Journal of Cell Biology Supplement (35): 65

Ivanova, E.S.; Rudoi, N.M., 1994: Tasks of the antituberculosis dispensary under current conditions. Problemy Tuberkuleza 0(2): 4-5

Rodriguez, T., 1999: Growth dynamics of two weeds: Sorghum halepense (L.) Pers. and Cyperus rotundus L. The growth dynamics of S. halepense and C. rotundus originating from seeds and rhizomes, and tubers, respectively, were examined. S. halepense seedlings from bud rhizomes showed the greatest amount of growth. Sprouting and survival was greater in...

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San Clemente, C.L., 1943: Protein fractionation and separation in the large Tiselius cell. Fresh serum is diluted 1:2.5 with buffer and dialyzed 1 day in 2 liters of the same buffer. Electrophoresis is carried out until the main components are separated over ?[image] of the length of the channel. The middle section is moved to one side....

Thompson, R.C.aig; Wilkie, S.C.arles, 1999: Glycopeptide hexapeptides. Official Gazette of the United States Patent & Trademark Office Patents 1226(2), Sep 14

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