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Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging


, : Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging. Journal of the American Geriatrics Society 41(7): 715-721

Objective: To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. Design: Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe total chromagen method. Fifteen clearance-estimating equations were evaluated for bias, accuracy, correlation with measured clearance values, and frequency of erroneous placement into renal function categories. Stepwise regression modeling and reliability testing were performed on a split sample to construct and assess a novel creatinine-clearance-estimating equation. Setting: New Haven, Connecticut, East Boston, Massachusetts, and a five-county region in and around Durham. North Carolina. Participants: A subsample of community-dwelling men and women (age range 70-79 years) from the Established Populations for Epidemiological Studies of the Elderly was screened for physical and cognitive functioning and placed into high-, medium-, and low-functioning groups (n = 1354). High-functioning respondents who provided blood and complete urine samples (n = 762) were included in the present study. Results: In general, estimated creatinine clearance was more closely correlated to measured values in males than in females. Most equations underestimated creatinine clearance, with average bias ranging from -33.1 mL/min to +19.6 mL/min. Predictive accuracy ranged from 18.2 mL/min to 38.0 mL/min. Equations were variable in their erroneous placement of individuals into renal function categories. Regression modeling yielded an equation which contained novel components but failed to provide better estimates of creatinine clearance than those already available. Conclusions: The equations evaluated here provide unacceptable predictions of creatinine clearance in normally aging individuals. We advocate the use of serum drug concentration measurements when available and encourage investigation into timed urine collections of short duration as alternatives to clearance-estimating equations in the elderly.

US$19.90

PMID: 8315180

DOI: 10.1111/j.1532-5415.1993.tb07459.x


Other references

Anonymous, 1926: Insects Pests. Pests attacking cotton in South Carolina in 1925-26 included the boll weevil, which was less destructive than in the previous year; the cotton flea-hopper, Reut.

Wegener K., 1972: Changes in the metabolism of dna sulfated muco poly saccharides and collagen in arterio sclerotic wall lesions visualized in the auto radiogram. Schlegel, B. Verhandlungen Der Deutschen Gesellschaft Fuer Innere Medizin. (proceedings Of The German Association For Internal Medicine.). Wiesbaden, West Germany. April 9-13,: Muenchen, West Germany. 1179-1197

Takahashi, H.; Shimada, I., 2007: Pairwise NMR experiments for the determination of protein backbone dihedral angle Phi based on cross-correlated spin relaxation. Novel cross-correlated spin relaxation (CCR) experiments are described, which measure pairwise CCR rates for obtaining peptide dihedral angles Phi. The experiments utilize intra-HNCA type coherence transfer to refocus 2-bond J(NC alpha) coupling...

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Barnes J.W.; Brown I.M., 1960: The geological environment of copper in Uganda. At the Kilembe copper mine, the Cu-Co mineralization occurs within the granulites of a granulite-amphibolite series correlated with the Toro system. Both epigenetic and syngenetic theories of origin have been proposed, and the problem has not been...

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Minhas, M.Raheel.; Kamal, R.; Afshan, G.; Raheel, H., 2005: Knowledge, attitude and practice of parturients regarding Epidural Analgesia for labour in a university hospital in Karachi. A study was conducted at the Aga Khan University Hospital, Karachi, Pakistan during November-December 2003. A total of 448 pregnant women scheduled for delivery were interviewed. Although 76% were aware of epidural analgesia as a means of relievin...

Knoop, E.K.amer, R.W.echen, A., 1974: Inspection of milk radioactivity in the German Federal Republic. Symposium: Kontamination und Dekontamination von Lebensmitteln: amination und Dekontamination 58-76

Guruprasad K.N.; Laloraya M.M., 1980: Effect of pigment precursors on the inhibition of antho cyanin biosynthesis by gibberellic acid and abscisic acid. Both GA and abscisic acid (ABA) inhibit synthesis of anthocyanin in radish [Raphanus sativus cv. Crimson French Breakfast] seedlings. Enrichment with precursors of anthocyanin nullifies the inhibition caused by GA but not the inhibition caused by...

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