geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Measuring carotid stenosis. Time for a reappraisal


, : Measuring carotid stenosis. Time for a reappraisal. Stroke 24(9): 1292-1296

Background and Purpose: Data from recent multicenter carotid endarterectomy trials have questioned the validity and reliability of Doppler ultrasound in the assessment of carotid stenosis. Methods: We prospectively analyzed 45 patients undergoing carotid angiography to compare the North American Symptomatic Carotid Endarterectomy Trial (NASCET) and European Carotid Surgery Trial (ECST) methods of measuring carotid stenosis with those of direct visualization ("eyeballing") and duplex ultrasound. Linear NASCET and ECST measurements were also converted into area using the pi r-2 function and termed "squared NASCET" (N-2) and "squared ECST" (E-2). In 15 of 45 patients undergoing carotid endarterectomy, the carotid plaque was removed intact, sectioned, and photographed for computer measurement of cross-sectional area. Comparison of this "gold standard" was then made to each method of measurement. Results: Comparison between duplex and the various angiographic measurement techniques revealed significant differences between NASCET and duplex (P lt .0001), ECST and duplex (P lt .01), and E-2 and duplex (P lt .01) but not between N-2, eyeballing, and carotid duplex methods. Even the NASCET and ECST methods themselves differed significantly (P lt .006). When comparison was made with computerized planimetric measurements of the carotid plaque, there were significant differences for both NASCET (P lt .0007) and ECST (P lt .007). Correlation was demonstrated only between planimetry and N-2, E-2, and duplex. Conclusions. NASCET and ECST angiographic methods of measurement consistently underestimate the "true" anatomic stenosis. As such, they represent only "indexes" of carotid stenosis severity. Duplex provides a more accurate measurement of carotid stenosis.

US$19.90

PMID: 8362420

DOI: 10.1161/01.str.24.9.1292


Other references

Kessler S.W.; Mushinski J.F.; Potter M.; Finkelman F.D., 1980: Dual processing of delta chains for secretion and for membrane deposition in murine immuno globulin d synthesizing plasma cytomas. Federation Proceedings 39(3): ABSTRACT 4141

Byard, R.W.; Thorner, P.S.; Cutz, E.; Filler, R.M.; Durie, P., 1990: Xanthogranulomatous cholecystitis and cholecystoduodenal fistula formation associated with total parenteral nutrition in a six year old child. A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN...

Thach, D.C.; Kleeberger, S.R.; Tucker, P.C.; Griffin, D.E., 2001: Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality. Neuroadapted Sindbis virus (NSV) infection of mice causes hindlimb paralysis and 100% mortality in the C57BL/6 mouse strain, while adults of the BALB/cBy mouse strain are resistant to fatal encephalomyelitis. Levels of viral RNA are higher in the...

Carapetis, J.R.; Russell, F.M.; Mansoor, O.; Darcy, A.; Fakakovi, T.; Metai, A.; Potoi, N.T.; Wilson, N.; Mulholland, E.K., 2008: Haemophilus influenzae type b infection in children in Pacific countries. The Haemophilus influenzae type b (Hib) disease burden among children under five years in four Pacific island countries (PIC was estimated. The incidence of confirmed Hib meningitis was calculated using numbers of culture confirmed isolates. In ad...

Alvarado Morillo, M., 2004: The effects of nutrient artery ligation on the development of the distal ulnar metaphysis of the dog. A total of 18 dogs were used in this study. They were obtained from the Veterinary Hospital of the University of Pennsylvania, Comparative Cardiovascular Studies Unit and from a dog pound of the Veterinary Policlinic, University of Zulia, Faculty...

Wollmann, G.; Davis, J.N.; Bosenberg, M.W.; van den Pol, A.N., 2013: Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes. Metastatic malignant melanoma remains one of the most therapeutically challenging forms of cancer. Here we test replication-competent vesicular stomatitis viruses (VSV) on 19 primary human melanoma samples and compare these infections with those o...

Vietor, I.; Vilcek, J., 1994: Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts. Treatment of human diploid FS-4 fibroblasts with TNF or IL-1 led to a rapid increase in the phosphorylation of a approximately 28-kDa protein. Increased phosphorylation was seen after 5 min of TNF treatment, it reached a plateau between 10 and 30...

Meurette J.; Delobelle A.; Laurent J.C.; Depadt G., 1982: Sarcoma of the body of the uterus. Journal de Gynecologie Obstetrique et biologie de la Reproduction 11(7): 823-828

Hall Edward A., 1982: Geological observations on the Montalvo Mounds, Ventura area, California. Pages 53-57 1982

Malabarba, M.G.; Rui, H.; Deutsch, H.H.; Chung, J.; Kalthoff, F.S.; Farrar, W.L.; Kirken, R.A., 1996: Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha. The lymphocyte growth factors interleukin-2 (IL2), IL4, IL7, IL9 and IL15 use the common IL2 receptor-gamma (IL2R gamma) and activate the IL2R gamma-associated tyrosine kinase JAK3 (Janus kinase 3). IL13 is structurally related to IL4, competes wi...