geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mechanism of caffeine modulation of the antitumor activity of adriamycin


, : Mechanism of caffeine modulation of the antitumor activity of adriamycin. Toxicology Letters (shannon). 75(1-3): 39-49

We examined the effects of a combination of adriamycin (ADR) and caffeine on DNA and protein biosynthesis and on the activities of DNA polymerase alpha and beta in normal and tumor tissue. The decrease in DNA and protein biosynthesis in tumor produced by caffeine combined with ADR were 2.5 and 2.4 times greater, respectively, compared with ADR alone. The combination of caffeine and ADR enhanced the decrease in DNA polymerases activities in the tumor which was induced by ADR, the decreases being 1.8 and 1.6 times greater, respectively, than that of ADR alone. In contrast, these ADR-induced changes in normal tissues were not enhanced by the combination with caffeine. The combination with caffeine had no effect on ADR concentration in normal tissues, but in the tumor, it increased the ADR concentration to 2.1 times that of ADR alone. In vitro, ADR efflux from Ehrlich ascites carcinoma cells was significantly inhibited by exposure to caffeine. These findings indicate that the effect of caffeine on ADR concentration in the cell plays an important role in the mechanism by which caffeine enhances ADR antitumor activity.

US$19.90

PMID: 7863536

DOI: 10.1016/0378-4274(94)03154-Y


Other references

Lee, B.Ju.; Kim, J.Yeol., 2016: Identification of Hemoglobin Levels Based on Anthropometric Indices in Elderly Koreans. Anemia is independently and strongly associated with an increased risk of mortality in older people and is also strongly associated with obesity. The objectives of the present study were to examine the associations between the hemoglobin level and...

Elonen, P.; Aho, L.; Koivistoinen, P., 1972: Influence of irrigation and nitrogen fertilization on the amino acid composition of spring wheat. In field trials in 1967-70, wheat grown with or without 2 irrigations in June, was given 16-97 kg N/ha + 43-63 kg P + 56-106 kg K/ha before sowing and in some plots an average of 76 kg N/ha was applied broadcast or incorporated 8 cm deep at sowing...

Bagatell C.J.; Mclachlan R.I.; Vale W.W.; Rivier J.E.; Bremner W.J., 1989: A gnrh antagonist nal glu plus testosterone a potential male contraceptive. Clinical Research 37(1): 106A

Sakamoto, T.; Inui, M.; Yasui, K.; Tokuda, S.; Akiyoshi, M.; Kobori, Y.; Nakaniwa, T.; Tada, T., 2012: Biochemical characterization and gene expression of two endo-arabinanases from Penicillium chrysogenum 31B. We previously described five arabinanolytic enzymes secreted by Penicillium chrysogenum 31B into the culture medium. Here, we describe a sixth such enzyme, termed AbnS1. Analysis of the reaction products of debranched arabinan revealed that AbnS1...

Pynnonen, B.W., 1996: A look at sucrose recovery via chromatographic separation. Sucrose recovery from molasses (also known as molasses desugarization) by ion exclusion is contributing 6-8% to the refined sucrose output of the beet sugar industry. A review of the sucrose recycling experience of the beet sugar industry, includi...

Andres, HG., 1981: Lysianassidae aus dem Abyssal des Roten Meeres. Bearbeitung der Koderfange von FS Sonne - MESEDA 1 (1977) (Crustacea: Amphipoda: Gammaridea). The gammaridean material was collected during MESEDA I (1977), Red Sea, by a baited phototrap in depths between 731-1869 m. All specimens are lysianassid amphipods. PSEUDAMARYLLIS nonconstricta gen. et sp. nov. Glycerina teretis sp. nov. and Socar...

Beranek B.; Dudek A.; Feifar M.; Hrdlicka A.; Suk M.; Zounkova Milada; Weiss J., 1972: The results of DSS measurements in cooperating countries; czechoslovakia. Geophysical Transactions = Geofizikai Kozlemenyek = Geofizicheskiy Byulletin' Pages 87-98

Tarassuk, N.P.; Frankel, E.N., 1957: The specificity of milk lipase. IV. Partition of the lipase system in milk. All cow's milk contains at least 2 different Upases: One, the "membrane lipase", which is irreversibly adsorbed onto the fat globules membrane material upon the cooling of freshly drawn milk; and the other the "plasma lipase&qu...

Crawley, G.R.; Grant, B.D.; Krpan, M.K.; Major, M.D., 1989: Long-term follow-up of partial limb amputation in 13 horses. Thirteen cases of partial limb amputation in horses were reviewed. Nine horses (69%) survived 18 to 111 months (mean, 41 months). Four unsuccessfully treated horses were euthanatized within 21 days of surgery. The horses' ages at amputation w...

S.Aközcan, A.U?ur Görgün, 2013: Trace metal and radionuclide pollution in marine sediments of the Aegean Sea Izmir Bay and Didim. To determine radioactivity and trace metal levels, surface sediments were collected from two important areas (?zmir Bay and Didim) in the Aegean Sea region of Turkey, and were analyzed for concentrations of <sup>210</sup>Po, <sup>...