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Modulation of macrophage inflammatory protein-1alpha and its receptors in human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma

, : Modulation of macrophage inflammatory protein-1alpha and its receptors in human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma. Biochemical and Biophysical Research Communications 235(3): 576-581

Macrophage inflammatory protein-1 alpha (MIP-1-alpha) is a member of the -C-C- family of low-molecular weight chemokines. MIP-1-alpha is involved in the homeostatic control of stem cell proliferation, in inducing chemotaxis, and also in inflammatory responses in mature cell types. In order to observe modulations of MIP1-alpha secretion and expression along with MIP-1-alpha receptor (MIP-1-alpha-R) expression for a possible autocrine role in AIDS associated B-cell lines, we studied a wide panel of human B-cell lines. Previous work by us has shown that HIV-1 tat down modulates MIP-1-alpha by inducing a novel transcription factor MNP. Our data in this report suggest that HIV down modulates MIP-1-alpha as a mechanism to evade suppression by this chemokine in human B-cells. Furthermore, our results strongly suggest MIP-1-alpha autocrine loops in a majority of tumor B-cells as evident by MIP-1-alpha-R expression, and also secretion of MIP-1-alpha.


PMID: 9207199

DOI: 10.1006/bbrc.1997.6828

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