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Myocardial atrial natriuretic factor gene expression after coronary ligation in rats


, : Myocardial atrial natriuretic factor gene expression after coronary ligation in rats. Experimental and Clinical Endocrinology 101(3): 173-177

The atrial natriuretic factor (ANF) messenger RNA (mRNA) content was determined in a rat model of acute myocardial infarction. Non-infarcted tissue of left and right ventricles were examined soon after ligation of the left descending anterior coronary arery. In the left ventricles, ANF mRNA/alpha-actin mRNA ratio increased to reach a maximum on day 7 and was sustained while in the right ventricle, the maximum was reached on day 1. The plasma ANF was significantly (p lt 0.01) elevated from days 1 to 28 after coronary ligation. The primary compensatory response of ANF within the first 7 days may be attributed not only to its synthesis in the left ventricle but also to its generation in the right ventricle in acute heart failure.

US$19.90

PMID: 8223987

DOI: 10.1055/s-0029-1211226


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