geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neonatal pattern of breathing during active and quiet sleep after maternal administration of meperidine


, : Neonatal pattern of breathing during active and quiet sleep after maternal administration of meperidine. Pediatric Research 32(4): 412-416

The aim of this study was to reappraise the effects of maternal meperidine administration on breathing pattern during the first hours of life taking into account the state of alertness. Because breathing instability is more pronounced during active sleep, we hypothesized that meperidine administration might create a greater risk for respiratory instability during active sleep, the prominent sleep state in newborns. We studied eight full-term, healthy newborns whose mothers had received a continuous i.v. infusion of meperidine (81 +- 9 mg ) that was terminated 5.5 +- 2.1 h before delivery. These infants were compared with a control group of eight full-term newborns whose mothers did not receive any opioids. In both groups, all babies were delivered vaginally after a normal labor and had Apgar scores of 9 or 10 at 1 and 5 min. Neonatal gastric secretion and maternal venous and umbilical venous blood were sampled at delivery for determination of meperidine concentration. From 60 to 300 min after delivery, behavioral sleep states and thoracic and abdominal movement as well as transcutaneous arterial oxygen saturation (SaO-2) were monitored continuously. The number of apneic spells lasting more than 3 s during 100 min of recording and the percentage of time with SaO-2 below 90% in each sleep state were recorded. During quiet sleep, all respiratory variables were similar in both groups. During active sleep, there were significantly more apneic episodes (37.1 +- 25.1 versus 11.2 +- 13.9) and a higher percentage of time with SaO-2 lt 90% (14.3 +- 16.7% versus 1.3 +- 1.5%) in the meperidine group than in the control group (p lt 0.01). In addition, the percentage of time with SaO-2 lt 90% was significantly correlated with maternal meperidine dose (p lt 0.02), drug-delivery interval (P lt 0.01), and gastric concentrations of meperidine (p lt 0.01). These data show that maternal administration of meperidine induces respiratory abnormalities in healthy, full-term newborns that occur only during active sleep. This result indicates that the state of alertness has to be characterized during the monitoring of long-term neonatal respiratory effects of any narcotic agent. In addition, we speculate that maternal meperidine administration may provoke more severe respiratory disturbances in at-risk neonates and that respiratory monitoring during the first hours of life may be useful in these newborns.

US$19.90

PMID: 1437393

DOI: 10.1203/00006450-199210000-00009


Other references

Czerniak, E.; Smiechowicz, J., 1979: Occurrence of trichinelliasis in domestic and wild pigs in the Olsztyn province. The average prevalence of trichinelliasis in the Olsztyn province of Poland, as based on official records of examinations at slaughter, was 0.0045% in domestic pigs for the years 1966-1974 and 0.1036% in wild boars for the years 1967-1977.

Niinuma K.; Tagawa M.; Hirano T.; Kikuyama S., 1991: Changes in tissue concentrations of thyroid hormones in metamorphosing toad larvae. Thyroid function of metamorphosing toad (Bufo japonicus) tadpoles was examined by following the changes in thyroxine (T4) and triiodothyronine (T3) concentrations in the tissue as well as the uptake of iodine by the thyroid. Thyroid hormone levels...

Giele, H., 2008: 'That's not erythema ab igne, that's a burn'. Journal of Plastic, Reconstructive & Aesthetic Surgery 62(1): 120-120

Bowes B.G., 1975: Light and electron microscopic observations on tylosis development in the excised root of taraxacum officinale. Flora (Jena) 164(1): 27-36

Mannebeck, H., 1984: Liquid manure systems. Dtw. Deutsche Tierarztliche Wochenschrift 91(1): 27-31

Saini, K.S.; Sidhu, J.S., 1997: Effect of different levels of nitrogen and row spacings on the yield performance of gobhi sarson (B. napus L.) sown on different dates. In a field experiment in 1990/91 at Amritsar, Indian Punjab, gobhi sarson [Brassica campestris var. sarson] cv. GSL-1 was sown on 1, 15 or 30 October or 15 November at row spacings of 30, 45 or 60 cm and given 50, 100 or 150 kg N/ha. The optimum s...

Pullman Erik; Jorgenson M.T.rre; Shur Yuri, 2008: Soil carbon distribution in the Alaska Arctic Coastal Plain. Extended Abstracts - International Conference on Permafrost 9: 245-246

Dietzsch, H.J., 1962: Malignant retothelial proliferations in childhood and their differential diagnostic delineation. Archiv für Kinderheilkunde 166: 253-265

Ebisawa, A., 1990: Reproductive biology of Lethrinus nebulosus Pisces Lethrinidae around the Okinawan waters. Bulletin of the Japanese Society of Scientific Fisheries 56.12: 1941-1954

Levy, S.E.; Simmons, D.H., 1974: Redistribution of alveolar ventilation following pulmonary thromboembolism in the dog. Journal of Applied Physiology 36(1): 60-68