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Neural mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs


, : Neural mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs. American Journal of Physiology 265(1 Pt 2): H103-H107

Basilar arterial diameters were angiographically measured in anesthetized dogs in which systemic blood pressure and heart rate were also monitored. Injections of N-G-nitro-L-arginine (L-NNA), a NO synthase inhibitor, into the cisterna magna produced a significant, persistent decrease in arterial diameter, the effect being reversed by intracisternal injections of L-arginine. The vasoconstrictor effect of L-NNA was diminished in dogs treated with hexamethonium. On the other hand, treatment with phentolamine in a dose sufficient to lower blood pressure to a level similar to that attained with hexamethonium did not inhibit, but rather potentiated, the effect of intracisternal L-NNA. Nicotine injected into the vertebral artery significantly dilated the basilar artery. The effect was abolished by treatment with L-NNA applied intracisternally, the inhibition being reversed by the addition of L-arginine. Systemic blood pressure and heart rate were not altered by intracisternally applied L-NNA and L-arginine. These findings support the hypothesis that basilar arterial constriction caused by intracisternal L-NNA is associated with a suppression of NO synthesis in nitroxidergic nerves innervating the cerebroarterial wall rather than an elimination of basal release of NO from the endothelium. Functional importance of nitroxidergic vasodilator innervation in cerebral arteries in vivo is thus clarified.

US$29.90

PMID: 8342620


Other references

Kreel, I.; Canter, J.W.; Segal, R.L.; Frankel, A.; Baronofsky, I.D., 1960: The influence of thyroidectomy on experimental ascites. Surgical Forum 10: 125-128

Tjader, I.E.; Essen, P.; Hultman, E.; Forsberg, A.; Wernerman, J., 2000: Glutamine supplementation to ICU patients affects lactate metabolism in skeletal muscle. Clinical Nutrition (Edinburgh) 19(Supplement 1): 46, August

Green, JE., 1974: The waved black moth (Parascutia fuliginaria L.) in Worcestershire. Entomologist's Record and Journal of Variation, 863: 92-93

Argaud, R., 1905: Sur la structure des arteres chez les Reptiles et en particulier sur le mode de transition du type elastique au type musculaire. Bibliographie Anatomique Nancy, 14 243-246

Moriske, H.J., 2001: Not Available. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 44(9): 924-928

Liu, Q.; Zhang, X-Lin.; Tao, R-Ya.; Niu, Y-Jing.; Chen, X-Guang.; Tian, J-Ying.; Ye, F., 2011: Rhein, an inhibitor of adipocyte differentiation and adipogenesis. Rhein (RH), a compound purified from Radix et Rhizoma Rhei, has been used to alleviate liver and kidney damage. It is found that RH inhibited the differentiation of 3T3-L1 preadipocytes induced by differentiation medium in a time- and dose-depende...

Gurrieri, J., 2012: ICD-10's impact on staffing: planning and partnership now brings relief in 2013. Health Management Technology 33(2): 40-40

Sawaki K.; Ishii Y.; Kawaguchi M., 1987: Effects of monoamine related drugs on the convulsive activity induced by procaine with reference to monoamines in rat spinal cord. Japanese Journal of Pharmacology 43(SUPPL): 261P

Ito, M.; Tanita, T., 1962: Study on dermal melanin-cell in silky fowl. Japanese Jour Dermatol 72(7): 616

Taliansky-Chamudis, A.; Gómez-Ramírez, P.; León-Ortega, M.; García-Fernández, A.J., 2017: Validation of a QuECheRS method for analysis of neonicotinoids in small volumes of blood and assessment of exposure in Eurasian eagle owl (Bubo bubo) nestlings. Neonicotinoid pesticides have gained great interest in the last years both for agricultural and domestic use. Since the information on their environmental distribution or the effects derived from exposure to ecosystems and biota is scarce, new ana...