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New derivatives of pyrrolo (3,2-e) (1,2,4) triazolo-(1,5-c)-pyrimidines


, : New derivatives of pyrrolo (3,2-e) (1,2,4) triazolo-(1,5-c)-pyrimidines. Egyptian Journal of Pharmaceutical Sciences 33(3-4): 473-484

2- Amino-4,5- diphenyl -1- methylpyrrolo-3-carbonitrile (I), reacted with triethyl orthoformate to give the 2-ethoxymethyleneamino-4,5- diphenyl-1-methyl-pyrrole-3-carbonitrile (II). The latter compound was converted into 5,6-diphenyl-3H, 4H, 4-imino-7-methylpyrrolo (2,3-d) pyrimidine-3-amine (III). Reaction of (III) with alpha-cyanocinnamonitrile derivatives (IV a,b) produced the 2-aryl-8,9-diphenyl-7-methyl- pyrrolo (3,2-e) (1,2,4) triazolo (1,5-c) pyrimidine (V a,b).

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