+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Normal post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels

, : Normal post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels. Cardiology 86(6): 451-456

Recent epidemiologic studies confirm that heavy physical exertion can trigger myocardial infarction. Diagnosis of acute myocardial injury in marathon runners is complicated by elevations of serum creatine kinase MB isoenzyme activity in asymptomatic finishers with normal post-race infarct-avid myocardial scintigraphy. Such isoenzyme elevations can arise from exertional rhabdomyolysis of skeletal muscle biochemically altered by training, from silent injury to the myocardium or from a combined tissue source. To assess silent myocardial cell necrosis in marathon runners, we performed quantitative antimyosin myocardial scintigraphy after competition with serum immunoassays for creatine kinase MB isoenzyme and troponin T. Therefore, 8 male marathon runners with a mean age of 52 years underwent quantitative antimyosin myocardial scintigraphy immediately following the 1988 and 1993 Boston Marathons. Serum immunoassays for creatine kinase MB isoenzyme by a chemiluminescent method (CLIA) and troponin T by an enzyme-linked immunosorbent assay were performed in 4 runners after the 1993 race. Quantitative antimyosin myocardial scintigraphy was normal in all runners including 3 who participated after both races 5 years apart. Post-race serum creatine kinase MB isoenzyme and/or troponin T levels were in a range otherwise diagnostic of acute myocardial infarction in 3 of 4 subjects. Normal quantitative antimyosin myocardial imaging in asymptomatic marathon runners excludes silent myocardial cell necrosis as the source of elevated serum protein markers. Such imaging may be the optimal diagnostic modality for detection of myocardial cell necrosis in symptomatic athletes when results of conventional testing are inconclusive.


Other references

Carel Keuls, 2008: Knowledge network development in water resources and irrigation management: the case of CKNet-INA in Indonesia. Irrigation and Drainage 57(3): 341-353

Renold, C.; wintsch, J.; Filthuth, I.; Wunderli, W.; Lew, D.; Hirschel, B., 1995: Pneumonia and respiratory distress syndrome during primary infection with Toxoplasma gondii. A 26-year-old Swiss male who had been HIV positive since 1987, began complaining of a dry cough. Tests for Toxoplasma gondii antibodies were negative. Two months later the patient was admitted to hospital with a fever, cough and a bilateral inters...

Sites, J W.; Jr.; Dixon, JR., 1982: Geographic variation in Sceloporus variabilis, and its relationship to S. teapensis (Sauria: Iguanidae). Copeia, 1: 14-27

Skapski, H.; Pyzik, T., 1990: Timing of tomato production for processing in Poland. During 1986-88, 3 early, dwarf cultivars, Beta 3, 11 and 40 were grown on 2 soil types (a sandy loam and an alluvial loam) near Warsaw and their yields and harvesting times were compared with those of 2 standard cultivars, New Yorker and Kujawski....

Rahman, K.A.; Singh, D.; Cheema, P.S.ngh, 1947: Field studies on sugarcane black bug. Population of the pest on each part of 300-500 canes was recorded during the 2d half of Aug. Vars. having broad and loosely attached leaf sheaths were more heavily infested. Heavy infestation was mostly confined to the 3d to 6th leaf-sheaths.

Dunsmore, D.G.; French, R.A., 1978: A simulator for evaluating the performance of recirculation cleaning systems. The simulator described in this paper has been designed to evaluate cleaning performance, by determining soil accumulation, corrosion and bacterial development on test pieces of various materials which are placed within modular glass tubes that fo...

Keenan, K.P.; Saffiotti, U.; Stinson, S.F.; Riggs, C.W.; McDowell, E.M., 1989: Morphological and cytokinetic responses of hamster airways to intralaryngeal or intratracheal cannulation with instillation of saline or ferric oxide particles in saline. The morphological and proliferative effects of intratracheal cannulation (ITC) or intralaryngeal cannulation (ILC), with or without the instillation of saline or Fe2O3 particles in saline, were studied in Syrian golden hamsters. Instillation of Fe...

Doxey, D., 1953: Use of radioactive iodine in the study of a plant growth -regulator. 2-Iodo-4-chloro-phenoxyacetic acid labelled with I131 was applied to leaves of young broad bean and oat plants. Movement of I131 was followed by means of autoradiographs. A high proportion of the applied material was absorbed, and rapidly transloc...

Heikkinen, T., 2006: A burden of influenza among children. Duodecim; Laaketieteellinen Aikakauskirja 122(3): 251-252

Marron J.A.; Waring G.O.IIi, 1980: Manometer for calibration of the mackay marg tonometer. Annals of Ophthalmology 12(11): 1344-1346