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Novel delivery of pancreatic islet cells to treat insulin-dependent diabetes mellitus


, : Novel delivery of pancreatic islet cells to treat insulin-dependent diabetes mellitus. Clinical Pharmacokinetics 28(6): 471-482

Immune protective devices containing pancreatic islets are designed to treat insulin-dependent diabetes mellitus by providing glycaemic control without immunosuppression. The immune protection is achieved by separating allogeneic or xenogeneic islets from the host by semipermeable membranes that allow only small molecules such as glucose, insulin and nutrients to pass through. Lymphocytes and immunoglobulins are excluded by the membrane and unable to cause rejection of the islets. Three types of immune protective devices, i.e. microcapsules, diffusion chambers and perfusion devices (vascularised artificial pancreas), have been studied. Microcapsules injected into the abdominal cavity in a large quantity achieved glycaemic control, but required a small amount of immunosuppression to prevent fibrosis around the the capsules. A clinical attempt to use microcapsulated human islets in a diabetic patient who has maintained functional kidney allografts has been reported. Intra-abdominal placement of diffusion chambers containing allogeneic islets achieved excellent glycaemic control without immunosuppression in diabetic dogs. However, their use was limited by the eventual breakage of tubular chambers. We have extensively used the vascularized artificial pancreas for treatment of experimental diabetes mellitus. Excellent biocompatibility of the device was evidenced by the extraordinary longevity of the patency of the device in healthy dogs. Long term control of severe diabetes mellitus was achieved in totally pancreatectomised dogs without immunosuppression by devices seeded with allogeneic (canine) and xenogeneic (porcine) islets. The vascularised artificial pancreas could be an excellent alternative to Diabetes Control and Complication Trial (DCCT)-type intensive insulin therapy or pancreatic transplantation by providing tight glycaemic control with minimal exogenous insulin therapy without immunosuppression.

US$19.90

PMID: 7656505

DOI: 10.2165/00003088-199528060-00005


Other references

Harris, A.C.; Ben Ezra, J.M.; Contos, M.J.; Kornstein, M.J., 1996: Malignant lymphoma can present as hepatobiliary disease. BACKGROUND. Liver involvement by non-Hodgkin's lymphoma usually represents systemic progression of a low grade lymphoma. Sixteen patients without palpable lymphadenopathy who presented with features suggesting hepatic inflammation were found...

Bayley, S.T.; Morton, R.A., 1978: Recent developments in the molecular biology of extremely halophilic bacteria. Crc Critical Reviews in Microbiology 6(2): 151-205

Vernotico, V.; Zanella, B., 1975: Colpocytological patterns after prolonged treatment with combined estroprogestinic drugs. Minerva Ginecologica 27(6): 448-456

Wardwell R.E.; Walker S.E.; Atwell J.S., 1977: Geotechnical aspects of papermill sludge disposal. Pages 756-772 1977

Mainstone, B.J., 1971: Environmental influences and the importance of covers and shade for cocoa. Part 1. This review deals with the effects upon cacao physiology of temperature, humidity, light intensity and available soil moisture, and continues with a survey of work on cacao establishment in association with mulches, cover crops and nurse shade pla...

Landry, L.G., 2007: Characterization of women's occupational musculoskeletal exposures. Although women are often characterized as having "safe" occupations, they are at risk of experiencing occupational musculoskeletal injuries. This cross-sectional study examined the health status, occupations, and job tasks of a random sa...

Goldstein, J.M., 1997: Industrial waste as fertilizer: what's wrong? What's right?. Critical issues in fertilizer regulations covering the reuse of industrial residuals are examined. Findings from studies on the use of industrial wastes in agriculture are discussed. The detection and determination of heavy metals and pathogens in...

Arato, K.M.tyas, L., 1984: Portugals joining to EEC.. Gazdalkodas 8(4): 63-68

Gudehus, H.C., 1976: Determination of air exchange figures with regard to closed greenhouses. Air exchange rates may be measured by forcing air into a greenhouse using a fan that draws air through a wind tunnel. The method is meant to provide comparisons between the leakage rates of greenhouses.

Yerganian, G.; Leonard, M.J., 1961: Maintenance of normal in situ chromosomal features in long-term tissue cultures. Clonal isolates from a rapidly proliferating fibroblast-like derivative have retained the classic diploid chromosome relationship over a period of many transplant generations. The readily identified members of the 11 pairs of chromosomes, includin...