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Novel Y-2-selective, reduced-size agonists of neuropeptide Y

, : Novel Y-2-selective, reduced-size agonists of neuropeptide Y. Bioorganic & Medicinal Chemistry Letters. 3(5): 937-942

The prerequisite for Y-2-mediated biological activity was elaborated by synthesizing analogs of neuropeptide Y (NPY) 1,4-Ahx-25-36. The finding, that a pronounced hydrophobic segment is required in the C-terminal segment for signal transduction led to the development of a Y-2-selective agonist, which contains cyclohexylalanine at position 30 and/or 31.


DOI: 10.1016/s0960-894x(00)80696-4

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