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Oxidant-mediated proteolytic activation of Ca-2+-ATPase in microsomes of pulmonary smooth muscle

, : Oxidant-mediated proteolytic activation of Ca-2+-ATPase in microsomes of pulmonary smooth muscle. Febs Letters. 387(2-3): 171-174

Treatment of bovine pulmonary artery smooth muscle tissue microsomes with H2O2 (1 mM) markedly stimulated protease activity tested with a synthetic substrate N-benzoyl-DL-arginine p-nitroanilide (BAPNA), and also enhanced Ca(2+)-ATPase activity. ATP-dependent Ca(2+) uptake was found to be stimulated upon treatment of the microsomes with H2O2. Pretreatment of the microsomes with vitamin E and aprotinin prevented the H2O2-induced stimulation of Ca(2+)-ATPase activity and also ATP-dependent Ca(2+) uptake. In contrast, H2O2-induced inhibition of Na(+)-dependent Ca(2+) uptake was reversed by vitamin E and aprotinin.


PMID: 8674543

DOI: 10.1016/0014-5793(96)00471-1

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