+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Parameters affecting in-liquid drying microencapsulation and release rate of cefaclor

, : Parameters affecting in-liquid drying microencapsulation and release rate of cefaclor. International Journal Of Pharmaceutics (amsterdam). 172(1-2): 113-125,. 15

An in-liquid drying microencapsulation method for producing sustained release cefaclor (CF) microspheres has been developed. Sieved fractions of CF monohydrate particles together with polyvinylpyrrolidone (Mw apprx40 000) were dispersed in a solvent mixture of dichloromethane with cyclohexane (40:60 v/v) containing dissolved ethylcellulose (EC; 48-49.5% ethoxy content). Encapsulation was effected by adding the dispersion to a stirred aqueous medium saturated with CF. The resulting microspheres (collected overnight and oven-dried at 40degreeC) were examined for size and surface features by scanning electron microscopy, and for solid-state interactions and phase changes using differential scanning calorimetry (DSC), thermogravimetric analysis and powder X-ray diffractometry. The rate and extent of CF release in aqueous medium was measured at 37degreeC using the USP rotating basket method at 100 rpm. The size, degree of sphericity, and rate of CF release of the microspheres were all shown to depend on the CF to EC mass ratio and the stirring speed employed in encapsulation. Higher EC to CF mass ratio and lower stirring speed afforded microspheres with slower release rate of CF. The rate of CF release from the microspheres fit the simplified Higuchi's planar model equation, and for the samples prepared at various EC:CF ratios, exhibited a strong correlation with drug loading (r = 0.98; n = 4 (mean values); p < 0.05). DSC studies on the samples indicated an absence of molecular interactions between. EC and CF in the microspheres. The results demonstrate that the in-liquid drying method, if appropriately optimized, could be used to produce sustained-release CF microspheres with the desired release pattern and physical properties.


DOI: 10.1016/s0378-5173(98)00199-9

Other references

Bimstein, E.; Katz, J., 2010: Obesity in children: a challenge that pediatric dentistry should not ignore--review of the literature. The link between childhood oral diseases and obesity is demonstrated by their increasing prevalence, potential cause and effect relationship, the significant deleterious effect on the child's present and future oral and systemic health, and t...

Brodsky, J.B.; Adkins, M.O.; Gaba, D.M., 1989: Bronchial cuff pressures of double-lumen tubes. Pressure damage to respiratory mucosa from overinflation of bronchial cuffs has been implicated as a cause of bronchial rupture, a rare but devastating complication of double-lumen endobronchial tubes (DLTs). We compared the pressure/volume charac...

Creemers, P.; Brugmans, W.; Vanmechelen, A., 1995: The anilino-pyrimidines, an interesting new fungicide family to control fungal diseases in fruit culture. The anilino-pyrimidines are a new fungicide family which has shown a good efficacy against two major fungal diseases in fruit culture namely grey mould (Botrytis cinerea) and scab on apple (Venturia inaequalis). At the moment there are three activ...

Janal, D., 1997: Ten ways to increase sales on your Internet Web site. Arbor age 17(1): 38-39

Goodall, R.M.; Hammes, M.R., 1986: Electronic comparison of toe strengths for diagnosis of lumbar nerve root lesions. Medical & Biological Engineering & Computing 24(5): 555-557

Smalley, B.W.; Loecker, T.H.; Collins, T.R.; Prince, T.S.; Browning, S.R., 2001: Positive predictive value of cardiac fluoroscopy in asymptomatic U.S. Army aviators. The primary aim of this study was to determine the positive predictive value (PPV) of cardiac fluoroscopy in U.S. Army aviators. Cardiac fluoroscopy is one of the non-invasive tests used to screen for coronary artery disease (CAD) in the U.S. Army...

Mewes, T.; Dutz, S.; Ravens, U.; Jakobs, K.H., 1994: Evidence for G-protein involvement in spontaneous activity of cardiac empty beta-adrenoceptors. Naunyn-Schmiedeberg's Archives of Pharmacology 349(SUPPL ): R10

Little, C.B.; Meeker, C.T.; Golub, S.B.; Lawlor, K.E.; Farmer, P.J.; Smith, S.M.; Fosang, A.J., 2008: Erratum. [This corrects the article on p. 3812 in vol. 118.].

Moody T.C.; Carr G.R.; Huang B., 1992: Lead isotopes from volcanogenic massive sulphides at Halls Peak, NSW. Pages 59-63 1992

Stottman, M.J., 2007: Out of sight, out of mind: privy architecture and the perception of sanitation. Historical Archaeology 34(1): 39-61