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Parameters of the fibrinolytic system in patients undergoing BMT: elevation of PAI-1 in veno-occlusive disease

, : Parameters of the fibrinolytic system in patients undergoing BMT: elevation of PAI-1 in veno-occlusive disease. Bone Marrow Transplantation 14(5): 747-750

Veno-occlusive disease (VOD) represents one of the more frequent and most severe complications after BMT. The pathophysiology of VOD is poorly understood. To investigate a possible link between endothelial cell damage and VOD, tissue plasminogen activator (tPA) and its inhibitor (PAI-1) were measured in 32 patients as endothelial cell-derived parameters of the fibrinolytic system. A nearly fivefold increase (mean 103.9 ng/ml, range 22.6-582.4 ng/ml, p < 0.05) in PAI-1 levels was found in the four patients who developed VOD compared with patients without this complication (mean 22.2 ng/ml, range 1.4-131.6 ng/ml). No significant difference was found in tPA levels between patient groups with or without VOD or other complications following BMT, indicating a shift of the fibrinolytic balance towards hypofibrinolysis particularly in patients with VOD. We conclude that alterations of the fibrinolytic system occur in patients undergoing BMT. Hypofibrinolysis seems to be at least one factor in the pathogenesis of VOD and the determination of PAI-1 might be helpful for diagnosing the disease. Our data also may explain the reported successful treatment of VOD by recombinant tPA.


PMID: 7889007

Other references

Heppenstall, P.A.; Fleetwood Walker, S.M.; Dickinson, T., 1995: Antagonists at the glycine modulatory site of the NMDA receptor reverse neurokinin-1 receptor agonist facilitation of NMDA receptor evoked activity in the rat dorsal horn. Society for Neuroscience Abstracts 21(1-3): 1373

Siemon G.; Thoma R.; Keller R., 1974: Carbon mon oxide diffusion capacity and blood gases in obstructive respiratory diseases and their behavior during broncho dilation therapy. Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin 180: 906-908

Amurskiy G.I.; Solov yev N.N.; Zhabrev I.P.; Smaragdov V.V.; Talday V.A., 1978: Gas potential of above-salt strata in eastern Turkmenia. Geologiya Nefti i Gaza 1978(12): 1-9

Rinne, T., 2010: Activations of human auditory cortex during visual and auditory selective attention tasks with varying difficulty. The present study was designed to directly test the hypothesis that suppression of activations to task-irrelevant sounds contributes to the attention-related modulations of auditory cortex (AC) activations observed in previous fMRI studies. Subjec...

Granberry D.M.; Smittle D.A., 1980: Population density and its effect on yield of southern pea. Hortscience 15(3): 276

Iida, K.; Matsumoto, S.; Yahara, I., 1992: The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin. The exposure of cultured mammalian cells to elevated temperatures induces the translocation of actin and cofilin into the nuclei and the formation of intranuclear bundles of actin filaments decorated by cofilin (actin/cofilin rods). Cofilin has a...

Ozbas, Z.Y.sim; Aytac, S.A.kut, 1993: Incidence of Yersinia enterocolitica in samples of pasteurized milk. Pasteurized milk was investigated in Yersinia enterocolitica, a foodborne pathogen. For this purpose, 60 pasteurized milk samples were examined and 4 (6.7%) of the samples were found to be positive according to both, typical appearance on selectiv...

Lombardo, F.; Gifford, E.; Shalaeva, M.Y., 2003: In silico ADME prediction: data, models, facts and myths. A critical review of a very recent work in the field of in silico ADME prediction is presented with emphasis on the work published during the period 2000-2002, and several other review articles are mentioned in order to offer a broader view of the...

Allerheiligen S.B.; Ludden T.M.; Burk R.F.; Lane J.M., 1985: Steady state pharmacokinetics of pentane. Federation Proceedings 44(4): 1116

Foissner, W., 1996: Terrestrial ciliates (Protozoa, Ciliophora) from two islands (Gough, Marion) in the southern oceans, with description of two new species, Arcuospathidium cooperi and Oxytricha ottowi. Twenty-seven soil and moss samples from Gough Island (40 degrees 21'S, 09 degrees 53'E) and Marion Island (46 degrees 52'S, 37 degrees 51'E), two small volcanic elevations in the South Atlantic and southern Indian Oceans, were...