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Pharmacokinetics of analgesics, sedatives and anaesthetic agents during cardiopulmonary bypass

, : Pharmacokinetics of analgesics, sedatives and anaesthetic agents during cardiopulmonary bypass. British Journal of Anaesthesia 75(3): 344-351

CPB produces changes in the blood-gas partition coefficient dependent on the prime used and temperature. Fortunately, the overall effect for hypothermic CPB and a crystalloid prime is only +2%. A volatile agent started during hypothermic CPB takes longer to equilibrate and agents already in use need to re-equilibrate, potentially changing the depth of anaesthesia, until equilibration is complete. As these agents are metabolized to a small degree and washout is fast, the duration of action is not prolonged after CPB.


PMID: 7547056

DOI: 10.1093/bja/75.3.344

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