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Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity

, : Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity. American Journal of Clinical Oncology 20(6): 573-576

CI-980 (NSC 370147)-a synthetic mitotic inhibitor that binds to tubulin at the colchicine binding site - has significant activity against a broad spectrum of tumor models and greater in vitro cytotoxicity when given over >24 hours than 4 hours or less. Phase I studies demonstrated central nervous system (CNS) toxicity to be dose-limiting when CI-980 was administered as a 24-hour infusion.


PMID: 9391543

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