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Physical association with ras enhances activation of membrane-bound raf (RafCAAX)


, : Physical association with ras enhances activation of membrane-bound raf (RafCAAX). Journal of Biological Chemistry 272(16): 10345-8

The transforming activity of artificially membrane targeted Raf1 suggests that Ras-mediated recruitment of Raf1 to the plasma membrane is an important step in Raf1 activation. Cellular Ras is concentrated in the caveolae, a microdomain of the plasma membrane that is highly enriched in caveolin, glycosylphosphatidylinositol-anchored proteins, and signal transduction molecules. Growth factor stimulation recruits Raf1 to this membrane domain.

US$19.90

PMID: 9099670

DOI: 10.1074/jbc.272.16.10345


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