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Primary cutaneous T-cell lymphoma with an angiocentric growth pattern: Association with Epstein-Barr virus


, : Primary cutaneous T-cell lymphoma with an angiocentric growth pattern: Association with Epstein-Barr virus. British Journal of Dermatology 135(4): 638-643

We report a case of primary cutaneous T-cell lymphoma with an angiocentric growth pattern. The lesions had been confined for about 2.5 years to the skin, but there had been a gradual progression of the disease both clinically and histologically. We assessed the neoplastic clonality and the presence of Epstein-Barr (EB) virus genome in this case using immunohistochemistry, Southern blot analysis and RNA in situ hybridization. Clonal proliferation of a CD4+ alpha-beta T-cell phenotype was demonstrated. In addition, the clonal population harboured the EB virus genome, which suggested that the virus was involved in the pathogenesis of the disease, The patient has remained in remission for 10 months, and has received treatment with cyclophosphamide and prednisone.

US$19.90

PMID: 8915164

DOI: 10.1046/j.1365-2133.1996.d01-1058.x


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