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Primary cutaneous T-cell lymphoma: clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma

, : Primary cutaneous T-cell lymphoma: clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. Journal of Pathology 172(1): 53-60

Within the group of primary cutaneous T-cell lymphomas (CTCLs), mycosis fungoides (MF), Sezary's syndrome (SS), and CD30-positive lymphomas have been delineated as clinicopathological entities. Primary CTCLs that do not belong to one of these entities represent a heterogeneous and ill-defined group of neoplasms. This paper describes the clinical and histological features of 35 of such cases. The object of this study was to define prognostic parameters for this group of primary CTCLs. Using a slightly modified version of the updated Kiel classification, a subdivision was made into CTCL, pleomorphic, small cell type (n = 3); pleomorphic, medium-sized cell type (n = 6); pleomorphic, large cell type (n = 18); and immunoblastic lymphomas (n = 8). Altogether, these lymphomas had a poor prognosis with estimated 2- and 4-year survival rates of 53 and 22 per cent, respectively. Patients with pleomorphic, small and medium-sized cell lymphomas (n = 9) proved to have a significantly better survival that those with pleomorphic, large cell lymphomas (P = 0.032) and immunoblastic lymphomas (P = 0.008). Primary cutaneous immunoblastic lymphomas had the worst prognosis with an estimated 2-year survival rate of 14 per cent. Other parameters including age (P = 0.345), sex (P = 0.662), extent of skin lesions at presentation (P = 0.0854), and mode of initial treatment (P = 0.609) had no significant effect on the survival time. The results of this study suggest that primary CTCLs other than classical MF, SS, and CD30-positive lymphomas have a poor prognosis in most cases, and that the current classification may be a useful means of predicting the clinical behaviour in these lymphomas.


PMID: 7931828

DOI: 10.1002/path.1711720110

Other references

Flores, R.; Fonseca, R.; Tamayo, S.; Capote, J.; Miranda, O.; Salmon, N.; Vazquez, Y.J., 1985: Efficacy of febantel in 2.5% suspension against gastrointestinal parasites of sheep. Faecal examinations revealed that febantel at a dose of 1 mg/5 kg body weight in 10 sheep and at 1.5 mg/5 kg in a second group of 10 sheep was effective against the principal gastrointestinal helminths for 3 weeks, after which helminths began to r...

Losos, JB.; Mayer, GC., 1991: Biology of Anolis lizards symposium; 69th Annual Meeting of the American Society of Ichthyologists and Herpetologists, San Francisco 17-23 June, 1989. Anolis Newsletter, 1-144 No. 4

Behboodi, E.; Gutierrez Adan, A.; Anderson, G.B., 1997: Inadvertent sex selection in a protocol of in vitro bovine embryo production. Theriogenology 47(1): 265

Sloan, T.B.; Rogers, J.N.; Bready, L.L., 1996: Daily resident evaluation scores correlate with in-training examination scores. Anesthesiology (Hagerstown) 85(3A): A936

Lewis, J., 1988: Environmental problems: the situation. EPA journal 14(7): 27-29

Okidi, C.O., 1984: Management of natural resources and the environment for self-reliance. The paper was first presented at the African Regional Conference of the International Economic Association held at Addis Ababa. It discusses the management of natural resources and the environment as a critical sector in the establishment of a sel...

Yochelson E.L., 1983: A devonian aptychus cephalopoda from alabama usa. The Chattanooga Shale in northern Alabama has yielded part of a cephalopod aptychus. This is the 1st report of a Devonian aptychus in the USA and only the 4th report of aptychi in the Paleozoic of North America.

Jaszczak, R.J.; Chang, L.T.; Stein, N.A.; Moore, F.E., 1979: Whole-body single-photon emission computed tomography using dual, large-field-of-view scintillation cameras. A whole-body single-photon emission computed tomography system (SPECT) consisting of two large-field-of-view scintillation cameras mounted on a rotatable gantry, a minicomputer and a display station has been designed, constructed and evaluated. In...

de Brauwere, A.; Gourgue, O.; de Brye, B.; Servais, P.; Ouattara, N.Koffi.; Deleersnijder, E., 2014: Integrated modelling of faecal contamination in a densely populated river-sea continuum (Scheldt River and Estuary). In order to simulate the long-term (months-years) median Escherichia coli distributions and variations in the tidal Scheldt River and Estuary, a dedicated module was developed for the Second-generation Louvain-la-Neuve Ice-ocean Model (SLIM, www.c...

Lee, Roderick D., 2001: Inbred corn plant 09DSS1 and seeds thereof. According to the invention, there is provided an inbred corn plant designated 09DSS1. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant O9DSS1, and to methods for producing a corn plant produced by cross...